Evidence map›Paper›PMID 38275384›Full record

ArticleBiomedicines2023

Genetic Mutations Associated with Inflammatory Response Caused by HPV Integration in Oropharyngeal Squamous Cell Carcinoma.

Mai Atique, Isis Muniz, Fatemeh Farshadi, Michael Hier, Alex Mlynarek, Marco Macarella, Mariana Maschietto, Belinda Nicolau, Moulay A Alaoui-Jamali, Sabrina Daniela da Silva

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Mai AtiqueDepartment of Otolaryngology and Head and Neck Surgery, McGill University, Montreal, QC H3T 1E2, Canada.
Isis MunizDepartment of Otolaryngology and Head and Neck Surgery, McGill University, Montreal, QC H3T 1E2, Canada.
Fatemeh FarshadiDepartment of Otolaryngology and Head and Neck Surgery, McGill University, Montreal, QC H3T 1E2, Canada.
Michael HierDepartment of Otolaryngology and Head and Neck Surgery, McGill University, Montreal, QC H3T 1E2, Canada.
Alex MlynarekDepartment of Otolaryngology and Head and Neck Surgery, McGill University, Montreal, QC H3T 1E2, Canada.
Marco MacarellaDepartment of Otolaryngology and Head and Neck Surgery, McGill University, Montreal, QC H3T 1E2, Canada.
Mariana MaschiettoDepartment of Structural and Functional Biology, Institute of Biology, Universidade Estadual de Campinas (UNICAMP), Campinas 13084-225, SP, Brazil.ORCID 0000-0003-2589-3186
Belinda NicolauGraduate Program in Dentistry, Health Sciences Center, Federal University of Paraiba, Campus I, João Pessoa 58051-900, PB, Brazil.
Moulay A Alaoui-JamaliSegal Cancer Centre and Lady Davis Institute for Medical Research, Departments of Medicine and Oncology, Sir Mortimer B. Davis-Jewish General Hospital, Faculty of Medicine, McGill University, Montreal, QC H3T 1E2, Canada.
Sabrina Daniela da SilvaDepartment of Otolaryngology and Head and Neck Surgery, McGill University, Montreal, QC H3T 1E2, Canada.
Jewish General Hospital · CAMcGill University · CAUniversidade Federal da Paraíba · BRUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

CIHR 2020-2025RSBO-FRQS 2023-2024
6 · The paper itself

Abstract

(1) Background: Head and neck cancer (HNC) ranks as the sixth most prevalent cancer in the world. In addition to the traditional risk factors such as alcohol and tobacco consumption, the implication of the human papillomavirus (HPV) is becoming increasingly significant, particularly in oropharyngeal cancer (OPC). (2) Methods: This study is based on a review analysis of different articles and repositories investigating the mutation profile of HPV-related OPC and its impact on patient outcomes. (3) Results: By compiling data from 38 datasets involving 8311 patients from 12 countries, we identified 330 genes that were further analyzed. These genes were enriched for regulation of the inflammatory response (

Indexed as

head and neck cancerhuman papillomavirusmutational profileoropharyngeal squamous cell carcinomasprognosis

Identifiers

PMID38275384
PMCPMC10813733
OpenAlexW4390058784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.