Evidence map›Paper›PMID 38275364›Full record

ReviewBiomedicines2023

Oxidative Stress and the Pathogenesis of Aortic Aneurysms.

Matthew Kazaleh, Rachel Gioscia-Ryan, Gorav Ailawadi, Morgan Salmon

Abstract readReview
In one paragraph

Review in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Deficiency of p27Journal of vascular research · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matthew KazalehDepartment of Cardiac Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Rachel Gioscia-RyanDepartment of Anesthesiology, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Gorav AilawadiDepartment of Cardiac Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Morgan SalmonDepartment of Cardiac Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6252-2355

Funding

The Role of IL-1R1 in cell transitions in Aortic Aneurysm PathogenesisR01HL126668 · NHLBI · UNIVERSITY OF VIRGINIA · PI AILAWADI, GORAV · 2015 to 2019
$2.4M
Surgeon Scientist Training in Cardiac DiseasesT32HL166113 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Gorav Ailawadi, YUQING Eugene CHEN · 2023 to 2026
$1.4M
NHLBI NIH HHS R01 HL126668NHLBI NIH HHS T32 HL166113
6 · The paper itself

Abstract

Aortic aneurysms are responsible for significant morbidity and mortality. Despite their clinical significance, there remain critical knowledge gaps in the pathogenesis of aneurysm disease and the mechanisms involved in aortic rupture. Recent studies have drawn attention to the role of reactive oxygen species (ROS) and their down-stream effectors in chronic cardiovascular diseases and specifically in the pathogenesis of aortic aneurysm formation. This review will discuss current mechanisms of ROS in mediating aortic aneurysms, the failure of endogenous antioxidant systems in chronic vascular diseases, and their relation to the development of aortic aneurysms.

Indexed as

abdominal aortic aneurysmantioxidantaortic aneurysmoxidative stressreactive oxygen speciesthoracic aortic aneurysm

Identifiers

PMID38275364
PMCPMC10813769

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.