Evidence map›Paper›PMID 38275173›Full record

ArticleLab on a chip2024

Toward 3D printed microfluidic artificial lungs for respiratory support.

Elyse Fleck, Charlise Keck, Karolina Ryszka, Andrew Zhang, Michael Atie, Sydney Maddox, Joseph Potkay

Abstract read
In one paragraph

Article in Lab on a chip, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. 3D Membrane Microstructures for Increased Efficiency in Blood-Gas Transfer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elyse FleckECLS Laboratory, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA. jpotkay@umich.edu.ORCID 0000-0003-2688-3043
Charlise KeckECLS Laboratory, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA. jpotkay@umich.edu.
Karolina RyszkaECLS Laboratory, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA. jpotkay@umich.edu.
Andrew ZhangECLS Laboratory, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA. jpotkay@umich.edu.
Michael AtieECLS Laboratory, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA. jpotkay@umich.edu.
Sydney MaddoxECLS Laboratory, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA. jpotkay@umich.edu.
Joseph PotkayECLS Laboratory, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA. jpotkay@umich.edu.ORCID 0000-0003-0320-7130

Funding

Human-scale microfluidic artificial lungR01HL144660 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI POTKAY, JOSEPH ALLEN · 2019 to 2022
$2.6M
MicroCT 100S10RR026475 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOHN, DAVID H. · 2010 to 2010
$381k
3D Printed Microfluidic Artificial Lung for Veteran RehabilitationI01RX003920 · VA · VETERANS HEALTH ADMINISTRATION · PI Joseph Allen Potkay · 2023 to 2026
–
Toward 3D printed microfluidic artificial lungs for veteran rehabilitationI21RX002403 · VA · VETERANS HEALTH ADMINISTRATION · PI POTKAY, JOSEPH ALLEN · 2017 to 2020
–
NCRR NIH HHS S10 RR026475NHLBI NIH HHS R01 HL144660RRD VA I01 RX003920RRD VA I21 RX002403
6 · The paper itself

Abstract

Microfluidic artificial lungs (μALs) are a new class of membrane oxygenators. Compared to traditional hollow-fiber oxygenators, μALs closely mimic the alveolar microenvironment due to their size-scale and promise improved gas exchange efficiency, hemocompatibility, biomimetic blood flow networks, and physiologically relevant blood vessel pressures and shear stresses. Clinical translation of μALs has been stalled by restrictive microfabrication techniques that limit potential artificial lung geometries, overall device size, and throughput. To address these limitations, a high-resolution Asiga MAX X27 UV digital light processing (DLP) 3D printer and custom photopolymerizable polydimethylsiloxane (PDMS) resin were used to rapidly manufacture small-scale μALs

Indexed as

MicrofluidicsPulmonary Gas ExchangeAnimalsBiomimeticsLungPrinting, Three-DimensionalSheep

Identifiers

PMID38275173
PMCPMC10863644

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.