Evidence map›Paper›PMID 38275117›Full record

ArticleStroke2024

Dynamic Imaging of Blood Coagulation Within the Hematoma of Patients With Acute Hemorrhagic Stroke.

Muhammad E Haque, Seth B Boren, James Mills, Kerry G Schneider, Maria Parekh, Stuart M Fraser, Ivo Bach, Praveen Hariharan, Pamela J Zelnick, Felix S Guerra Castanon and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Muhammad E HaqueInstitute for Stroke and Cerebrovascular Diseases and Department of Neurology (M.E.H, S.B.B., K.G.S., M.P., S.M.F, I.B., P.H., P.J.Z., F.S.G.C., A.N., M.T., X.Z., J.A., S.I.S.).ORCID 0000-0002-1453-5618
Seth B BorenInstitute for Stroke and Cerebrovascular Diseases and Department of Neurology (M.E.H, S.B.B., K.G.S., M.P., S.M.F, I.B., P.H., P.J.Z., F.S.G.C., A.N., M.T., X.Z., J.A., S.I.S.).
James MillsDepartment of Psychiatry, University of Iowa, Iowa City (J.M.).
Kerry G SchneiderInstitute for Stroke and Cerebrovascular Diseases and Department of Neurology (M.E.H, S.B.B., K.G.S., M.P., S.M.F, I.B., P.H., P.J.Z., F.S.G.C., A.N., M.T., X.Z., J.A., S.I.S.).
Maria ParekhInstitute for Stroke and Cerebrovascular Diseases and Department of Neurology (M.E.H, S.B.B., K.G.S., M.P., S.M.F, I.B., P.H., P.J.Z., F.S.G.C., A.N., M.T., X.Z., J.A., S.I.S.).ORCID 0000-0003-0465-8400
Stuart M FraserInstitute for Stroke and Cerebrovascular Diseases and Department of Neurology (M.E.H, S.B.B., K.G.S., M.P., S.M.F, I.B., P.H., P.J.Z., F.S.G.C., A.N., M.T., X.Z., J.A., S.I.S.).ORCID 0000-0003-4390-0490
Ivo BachInstitute for Stroke and Cerebrovascular Diseases and Department of Neurology (M.E.H, S.B.B., K.G.S., M.P., S.M.F, I.B., P.H., P.J.Z., F.S.G.C., A.N., M.T., X.Z., J.A., S.I.S.).ORCID 0000-0003-2215-1240
Praveen HariharanInstitute for Stroke and Cerebrovascular Diseases and Department of Neurology (M.E.H, S.B.B., K.G.S., M.P., S.M.F, I.B., P.H., P.J.Z., F.S.G.C., A.N., M.T., X.Z., J.A., S.I.S.).ORCID 0000-0002-0115-3354
Pamela J ZelnickInstitute for Stroke and Cerebrovascular Diseases and Department of Neurology (M.E.H, S.B.B., K.G.S., M.P., S.M.F, I.B., P.H., P.J.Z., F.S.G.C., A.N., M.T., X.Z., J.A., S.I.S.).
Felix S Guerra CastanonInstitute for Stroke and Cerebrovascular Diseases and Department of Neurology (M.E.H, S.B.B., K.G.S., M.P., S.M.F, I.B., P.H., P.J.Z., F.S.G.C., A.N., M.T., X.Z., J.A., S.I.S.).ORCID 0000-0003-1721-4673
Asim NaveedInstitute for Stroke and Cerebrovascular Diseases and Department of Neurology (M.E.H, S.B.B., K.G.S., M.P., S.M.F, I.B., P.H., P.J.Z., F.S.G.C., A.N., M.T., X.Z., J.A., S.I.S.).
Muhammad TariqInstitute for Stroke and Cerebrovascular Diseases and Department of Neurology (M.E.H, S.B.B., K.G.S., M.P., S.M.F, I.B., P.H., P.J.Z., F.S.G.C., A.N., M.T., X.Z., J.A., S.I.S.).
Octavio D ArevaloDepartment of Radiology, Louisiana State University, Shreveport (O.D.A.).ORCID 0000-0001-5307-5012
Khader M HasanDepartment of Interventional Diagnostic Radiology (K.M.H., P.A.N., C.S.).ORCID 0000-0001-7538-2849
Miguel EscobarMcGovern Medical School, The University of Texas Health Science Center at Houston (M.E.).ORCID 0000-0002-2944-0240
Xiurong ZhaoInstitute for Stroke and Cerebrovascular Diseases and Department of Neurology (M.E.H, S.B.B., K.G.S., M.P., S.M.F, I.B., P.H., P.J.Z., F.S.G.C., A.N., M.T., X.Z., J.A., S.I.S.).ORCID 0000-0002-5135-1033
Clark SittonDepartment of Interventional Diagnostic Radiology (K.M.H., P.A.N., C.S.).ORCID 0000-0001-9926-9840
Ponnada A NarayanaDepartment of Interventional Diagnostic Radiology (K.M.H., P.A.N., C.S.).
James C GrottaStroke Research and Mobile Stroke Unit, Department of Neurology, Memorial Hermann Hospital, Houston, TX (J.C.G.).ORCID 0000-0002-3667-4248
Jaroslaw AronowskiInstitute for Stroke and Cerebrovascular Diseases and Department of Neurology (M.E.H, S.B.B., K.G.S., M.P., S.M.F, I.B., P.H., P.J.Z., F.S.G.C., A.N., M.T., X.Z., J.A., S.I.S.).ORCID 0000-0002-9256-7973
Sean I SavitzInstitute for Stroke and Cerebrovascular Diseases and Department of Neurology (M.E.H, S.B.B., K.G.S., M.P., S.M.F, I.B., P.H., P.J.Z., F.S.G.C., A.N., M.T., X.Z., J.A., S.I.S.).ORCID 0000-0003-4637-1790

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe dynamics of blood clot (combination of Hb [hemoglobin], fibrin, and a higher concentration of aggregated red blood cells) formation within the hematoma of an intracerebral hemorrhage is not well understood. A quantitative neuroimaging method of localized coagulated blood volume/distribution within the hematoma might improve clinical decision-making.

methodsThe deoxyhemoglobin of aggregated red blood cells within extravasated blood exhibits a higher magnetic susceptibility due to unpaired heme iron electrons. We propose that coagulated blood, with higher aggregated red blood cell content, will exhibit (1) a higher positive susceptibility than noncoagulated blood and (2) increase in fibrin polymerization-restricted localized diffusion, which can be measured noninvasively using quantitative susceptibility mapping and diffusion tensor imaging. In this serial magnetic resonance imaging study, we enrolled 24 patients with acute intracerebral hemorrhage between October 2021 to May 2022 at a stroke center. Patients were 30 to 70 years of age and had a hematoma volume >15 cm

resultsUsing a coagulated blood phantom, we demonstrated a linear relationship between the percentage coagulation and susceptibility (R

conclusionsThis quantitative neuroimaging study of coagulation within the hematoma has the potential to improve patient management, such as safe resumption of anticoagulants, the need for reversal agents, the administration of alteplase to resolve the clot, and the need for surgery.

Indexed as

Hemorrhagic StrokeStrokeBlood CoagulationCerebral HemorrhageDiffusion Tensor ImagingFibrinHematomaHemoglobinsHumansMagnetic Resonance ImagingFibrinHemoglobinsblood coagulationcerebral hemorrhagefibrinmagnetic resonance imagingquantitative phase imaging

Identifiers

PMID38275117
PMCPMC10962442

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