Evidence map›Paper›PMID 38274970›Full record

ArticleAsian journal of transfusion science

Application of blood group genotyping in complex cases of immunohematology.

Letícia Binhara Musial, Caroline Luise Prochaska, Mariane Faria Moss, Bruno Ribeiro Cruz

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian journal of transfusion science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Letícia Binhara MusialDepartment of Clinical and Toxicological Analyses, Ponta Grossa State University, Curitiba, Parana, Brazil.
Caroline Luise ProchaskaDivision of Production and Immunohematology, Hematology and Hemotherapy Center of Parana, Curitiba, Parana, Brazil.
Mariane Faria MossDepartment of Clinical and Toxicological Analyses, Ponta Grossa State University, Curitiba, Parana, Brazil.
Bruno Ribeiro CruzDepartment of Clinical and Toxicological Analyses, Ponta Grossa State University, Curitiba, Parana, Brazil.
Universidade Estadual de Ponta Grossa · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRed blood cell (RBC) group systems are depicted by antigens on the surface of RBCs, which when transfused to a recipient that lacks them, can result in alloimmunization. Thus, transfusion of matched RBC components to the recipient is recommended, especially for the more immunogenic blood group antigens, such as Rh (E, e, C, and c), Kell, Kidd, Duffy, and MNS.

aimsThe aim of this study was to perform the blood group genotyping from blood samples of 12 polytransfused patients whose phenotyping was inconclusive or incomplete.

methodsThe amplicons were amplified by polymerase chain reaction-sequence-specific primers for the following alleles: RHCE (

resultsDiscrepancies were found in the Rh (E) and Kidd systems, in addition to cases of Fyb antigen silencing attributed to the GATA mutation, which was present in all individuals with Fy (a-b-) phenotype. The technique also solved the inconclusive phenotyping caused by mixed-field agglutination.

conclusionThe results show the contribution of blood group genotyping in complex immunohematology cases, optimizing the delivery of RBC components suitable for transfusion safety, and expanding the number of compatible donors for patients with the Fy (a-b) phenotype related to the FY (

Indexed as

Blood transfusiongenotypinghematologyimmunohematologymolecular biologyred blood cell antigens

Identifiers

PMID38274970
PMCPMC10807531
OpenAlexW4390914808

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.