ReviewThe Japanese dental science review2024
Respiratory tract barrier dysfunction in viral-bacterial co-infection cases.
Review in The Japanese dental science review, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- An Appraisal of the Potential Downstream Benefits of RSV Vaccination in Older Adults.Reviews in medical virology · 2026Review
- Article
- Epidemiology, bacterial coinfection risk factors, and inflammatory markers in children with RSV, AdV, and hMPV pneumonia in Zunyi, China.BMC infectious diseases · 2026Article
- The impact of influenza vaccination on the clinical severity of influenza among children aged 6 months to 6 years living in the community: a prospective cohort study.Clinical and experimental vaccine research · 2026Article
- Viral-bacterial codetection and clinical and laboratory characteristics in children hospitalized with lower respiratory tract infections in a private hospital in Lima, Peru: a cross-sectional study.Tropical diseases, travel medicine and vaccines · 2026Article
- Epidemiological characteristics of human parainfluenza virus infection in hospitalized children: a single-center study.Frontiers in public health · 2026Article
- Infantile pulmonary abscess due toFrontiers in pediatrics · 2026Article
- Designing a broad-spectrum multi-epitope vaccine against influenza A andFrontiers in public health · 2026Article
- Risk Factors and Predictors of Pneumonia Among Under-Five Children in Sana'a City, Yemen: A Multicenter Case-Control Study.Pediatric health, medicine and therapeutics · 2026Article
- Clinical characteristics, co-detection patterns and prognostic risk factors of human metapneumovirus infection in children: a retrospective study.Frontiers in cellular and infection microbiology · 2026Article
- Epidemiological characteristics and changing patterns of hospitalizations among middle-aged and elderly patients in Northwest China, 2020-2024: A retrospective cohort study.SAGE open medicine · 2026Article
- Post-Translational Modifications in Respiratory Virus Infection: Recent Insights into the Development of In Vitro Models.International journal of molecular sciences · 2025Review
- The Increased Risk for Postinfluenza Pneumonia Among Cystic Fibrosis Carriers-A Population-Based Study.Open forum infectious diseases · 2025Article
- NF-κB driven inflammation mediates loss of upper airway epithelial tolerance tobioRxiv : the preprint server for biology · 2025Article
- Post-COVID-19 Epidemiology of Viral Infections in Adults Hospitalized with Acute Respiratory Syndromes in Palermo, South of Italy.Pathogens (Basel, Switzerland) · 2025Article
- Loss of pulmonary tissue protection and neutrophil microbicidal defects promote severeInfection and immunity · 2025Article
- Integrated Microbiome Data Analysis Reveals Potential Pneumonia Microbial Biomarkers in ICU Patients: A Machine Learning Approach.Current microbiology · 2025Article
- Temporal Changes in Nasopharyngeal Pneumococcal Colonization Density Associated With Respiratory Syncytial Virus and Influenza in a South African Household Cohort Study, 2016-2018.Open forum infectious diseases · 2025Article
- Harnessing Epigenetics: Innovative Approaches in Diagnosing and Combating Viral Acute Respiratory Infections.Pathogens (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A preceding viral infection of the respiratory tract predisposes the host to secondary bacterial pneumonia, known as a major cause of morbidity and mortality. However, the underlying mechanism of the viral-bacterial synergy that leads to disease progression has remained elusive, thus hampering the production of effective prophylactic and therapeutic intervention options. In addition to viral-induced airway epithelial damage, which allows dissemination of bacteria to the lower respiratory tract and increases their invasiveness, dysfunction of immune defense following a viral infection has been implicated as a factor for enhanced susceptibility to secondary bacterial infections. Given the proximity of the oral cavity to the respiratory tract, where viruses enter and replicate, it is also well-established that oral health status can significantly influence the initiation, progression, and pathology of respiratory viral infections. This review was conducted to focus on the dysfunction of the respiratory barrier, which plays a crucial role in providing physical and secretory barriers as well as immune defense in the context of viral-bacterial synergy. Greater understanding of barrier response to viral-bacterial co-infections, will ultimately lead to development of effective, broad-spectrum therapeutic approaches for prevention of enhanced susceptibility to these pathogens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.