Evidence map›Paper›PMID 38274894›Full record

ArticleFrontiers in chemistry2023

Microwave-assisted synthesis and development of novel penicillinoate@copper metal-organic frameworks as a potent antibacterial agent.

Adnan Hashim Abdulkadhim, Suhair Mohammad Husein Kamona, Haider Falih Shamikh Al-Saedi, Anmar Ghanim Taki, Abdul-Hameed M Hamoody, Sarah A Hamood, Safia Obaidur Rab, Ahmed Ali Amir, Ashwaq Talib Kareem, Ahmed Alawadi and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 3 countries.

Adnan Hashim AbdulkadhimDepartment of Computer Engineering, Technical Engineering College, Al-Ayen University, Thi-Qar, Iraq.
Suhair Mohammad Husein KamonaDepartment of Medical Laboratories Technology, Al-Manara College for Medical Sciences, Amarah, Iraq.
Haider Falih Shamikh Al-SaediDepartment of Pharmaceutical, Faculty of Pharmacy, University of Al-Ameed, Karbala, Iraq.
Anmar Ghanim TakiDepartment of Radiology and Sonar Techniques, Al-Noor University College, Nineveh, Iraq.
Abdul-Hameed M HamoodyDepartment of Medical Laboratories Technology, Al-Hadi University College, Baghdad, Iraq.
Sarah A HamoodDepartment of Medical Engineering, Al-Esraa University College, Baghdad, Iraq.
Safia Obaidur RabDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Ahmed Ali AmirDepartment of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq.
Ashwaq Talib KareemDepartment of Medical Engineering, College of Pharmacy, National University of Science and Technology, Dhi Qar, Iraq.
Ahmed AlawadiCollege of Technical Engineering, the Islamic University, Najaf, Iraq.
Ali IhsanDepartment of Medical Laboratories Techniques, Imam Ja'afar Al-Sadiq University, Al-Muthanna, Iraq.
Al-Ayen UniversityAl Mansour University College · IQAl-Nisour University College · IQAl Noor University CollegeAlrafidain University College · IQImam Ja’afar Al-Sadiq UniversityIraqi University · IQKing Khalid University · SANational University of Science and Technology · ZWUniversity of Karbala · IQ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, nanoscience, especially metal-organic frameworks (MOFs), has been used to increase the effectiveness and properties of drugs. In this study, by using microwave irradiation; penicillin, which is a known antibiotic; and copper metal-organic frameworks (Cu-MOFs), a new penicillinoate@copper metal-organic framework (penicillinoate@Cu-MOF) was synthesized. The structure and characterization of the newly synthesized compound were determined using FT-IR spectrums, EDAX analysis, elemental analysis, XRD patterns, SEM images, nitrogen adsorption/desorption curves, and TGA curve. Then, its antimicrobial effects were evaluated on numerous Gram-positive and Gram-negative bacterial strains and were compared with those of penicillin and gentamicin. In continuation of the biological activities, antioxidant tests were performed on the compounds using the DPPH method. For biological activities, the synthesized penicillinoate@Cu-MOF is much more effective than penicillin and Cu-MOF. The loading of penicillin on the nanostructure and the presence of copper in the final composition can be attributed to the high antibiotic properties of the synthesized composition.

Indexed as

copper metal–organic frameworkGram-negative bacterial strainsGram-positive bacterial strainsmicrowave irradiationpenicillin

Identifiers

PMID38274894
PMCPMC10808350
OpenAlexW4390744493

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.