Evidence map›Paper›PMID 38274813›Full record

ArticleFrontiers in immunology2023

Tick innate immune responses to hematophagy and

Abdulsalam Adegoke, Jose M C Ribeiro, Ryan C Smith, Shahid Karim

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Exploring new dimensions of immune cell biology inbioRxiv : the preprint server for biology · 2024
    Article
  7. Analysis ofbioRxiv : the preprint server for biology · 2024
    Article
  8. Article
  9. PathogenicJournal of bacteriology · 2024
    Review
  10. Analysis ofFrontiers in cellular and infection microbiology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Abdulsalam AdegokeSchool of Biological, Environmental, and Earth Sciences, The University of Southern Mississippi, Hattiesburg, MS, United States.
Jose M C RibeiroVector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, United States.
Ryan C SmithDepartment of Plant Pathology, Entomology, and Microbiology, Iowa State University, Ames, IA, United States.
Shahid KarimSchool of Biological, Environmental, and Earth Sciences, The University of Southern Mississippi, Hattiesburg, MS, United States.
University of Southern Mississippi · USIowa State University · USNational Institutes of Health · US

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
Sex differences in operant cocaine memoriesP20GM144041 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Ramona Moles · 2023 to 2026
$12.1M
Understanding alpha-gal red meat allergyR01AI135049 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Scott Palmer Commins · 2018 to 2026
$5.1M
Vector-Borne Diseases: Biology Of Vector Host RelationshipZ01AI000810 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI RIBEIRO, JOSE M · 1997 to 2008
$3.5M
Rational development of a vaccine against tick-borne rickettsiosesR01AI163857 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI FANG, RONG MEGAN · 2022 to 2025
$3.2M
PLURIPOTENCY OF NOVEL TICK CYSTEINE PROTEASE INHIBITORS DURING HEMATOPHAGYR15AI167013 · NIAID · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MORGAN, SARAH E · 2022 to 2022
$444k
Validation of the Regulatory Potential of Tailed MirtronsR15GM120716 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI FLYNT, ALEX · 2016 to 2016
$437k
The Role of Hemocytes in tick Rickettsia parkeri infectionR21AI175885 · NIAID · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI KARIM, SHAHID · 2024 to 2025
$407k
Intramural NIH HHS Z01 AI000810NIAID NIH HHS R01 AI135049NIAID NIH HHS R01 AI163857NIAID NIH HHS R15 AI167013NIAID NIH HHS R21 AI175885NIGMS NIH HHS P20 GM103476NIGMS NIH HHS P20 GM144041NIGMS NIH HHS R15 GM120716
6 · The paper itself

Abstract

Introduction: Ticks rely on robust cellular and humoral responses to control microbial infection. However, several aspects of the tick's innate immune system remain uncharacterized, most notably that of the immune cells (called hemocytes), which are known to play a significant role in cellular and humoral responses. Despite the importance of hemocytes in regulating microbial infection, our understanding of their basic biology and molecular mechanisms remains limited. Therefore, we believe that a more detailed understanding of the role of hemocytes in the interactions between ticks and tick-borne microbes is crucial to illuminating their function in vector competence and to help identify novel targets for developing new strategies to block tick-borne pathogen transmission. Methods: This study examined hemocytes from the lone star tick ( Results and discussion: Our data exhibit the identification of fourteen distinct hemocyte populations. Our results uncover seven distinct lineages present in uninfected and Conclusion: Our results uncover the tick immune responses to

Indexed as

Ehrlichia chaffeensisEhrlichiosisIxodidaeTicksAmblyommaAnimalsImmunity, Innate10X GenomicsAmblyomma americanumEhrlichia chaffeensishemocytesRNA-sequencingsingle cell

Identifiers

PMID38274813
PMCPMC10808623
OpenAlexW4390745394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.