ArticleFrontiers in immunology2023
A viral-specific CD4
Aryamav Pattnaik, Adeeba H Dhalech, Stephanie A Condotta, Caleb Corn, Martin J Richer, Laura M Snell, Christopher M Robinson
Open access · goldAbstract read
In one paragraphArticle in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors at 2 institutions in 1 country.
Aryamav Pattnaik *Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, United States.
Adeeba H Dhalech *Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, United States.
Stephanie A CondottaDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, United States.
Caleb CornDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, United States.
Martin J RicherDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, United States.
Laura M SnellDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, United States.
Christopher M RobinsonDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, United States.
Indiana University School of MedicineIndiana University – Purdue University Indianapolis · US
Funding
Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Jun Wan · 1999 to 2026
$59.3MProject-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7McGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1MSex-dependent replication of coxsackievirusK01DK110216 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI ROBINSON, CHRISTOPHER MICHAEL · 2016 to 2021
$732kContribution of host genetic factors to intestinal Coxsackievirus replicationR03DK124749 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI ROBINSON, CHRISTOPHER MICHAEL · 2020 to 2021
$229kNCI NIH HHS P30 CA082709NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIDA NIH HHS 75N95020D00005NIDDK NIH HHS K01 DK110216NIDDK NIH HHS R03 DK124749NIDDK NIH HHS U54 DK106846ORFDO NIH HHS 75N99020D00005
6 · The paper itselfAbstract
Background: Biological sex plays an integral role in the immune response to various pathogens. The underlying basis for these sex differences is still not well defined. Here, we show that Coxsackievirus B3 (CVB3) induces a viral-specific CD4+ T cell response that can protect female mice from mortality. Methods: We inoculated C57BL/6 Ifnar Results: We found that CVB3 can induce expansion of CD62Llo CD4+ T cells in the mesenteric lymph node and spleen of female but not male mice as early as 5 days post-inoculation, indicative of activation. Using a recombinant CVB3 virus expressing a model CD4+ T cell epitope, we found that this response is due to viral antigen and not bystander activation. Finally, the depletion of CD4+ T cells before infection increased mortality in female mice, indicating that CD4+ T cells play a protective role against CVB3 in our model. Conclusions: Overall, these data demonstrated that CVB3 can induce an early CD4 response in female but not male mice and further emphasize how sex differences in immune responses to pathogens affect disease.
Indexed as
Coxsackievirus InfectionsEnterovirus B, HumanAnimalsAntigens, ViralCD4-Positive T-LymphocytesFemaleMaleMiceMice, Inbred C57BLAntigens, ViralCD4 T cellsCoxsackievirus B3Enteric virussex differencesT cellsviral clearance
Identifiers
PMID38274806
PMCPMC10808549
OpenAlexW4390744811
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390