Evidence map›Paper›PMID 38274556›Full record

ArticleJournal of equine science2023

Pharmacokinetic/pharmacodynamic analysis of cephalothin after intramuscular administration in Thoroughbred horses.

Taisuke Kuroda, Yohei Minamijima, Hidekazu Niwa, Hiroshi Mita, Norihisa Tamura, Kentaro Fukuda, Minoru Ohta

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of equine science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 78% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Taisuke KurodaEquine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
Yohei MinamijimaLaboratory of Racing Chemistry, Tochigi 320-0851, Japan.
Hidekazu NiwaEquine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
Hiroshi MitaEquine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
Norihisa TamuraEquine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
Kentaro FukudaEquine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
Minoru OhtaEquine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
Japan Racing Association · JPLaboratory of Racing Chemistry · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A pharmacokinetic/pharmacodynamic (PK/PD) approach was used to determine a dosage regimen of cephalothin (CET) after intramuscular (IM) administration in horses. CET plasma concentrations were measured in eight horses after a single IM administration of 11 mg/kg bwt of CET. The data were modeled using a nonlinear mixed-effect model, and the probability of target attainment (PTA) of the PK/PD target was calculated for 5,000 horses generated by Monte Carlo simulations. IM administrations of CET at 11 mg/kg bwt q 8 hr and q 6 hr achieved a PTA of 90% against the MIC

Indexed as

cephalosporinsgram-positive bacteriaintramuscular administrationpharmacokinetics

Identifiers

PMID38274556
PMCPMC10806359
OpenAlexW4390958650

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.