Evidence map›Paper›PMID 38274442›Full record

ArticleFrontiers in medicine2023

Resurgence of influenza A after SARS-CoV-2 omicron wave and comparative analysis of hospitalized children with COVID-19 and influenza A virus infection.

Fen Lin, Man-Tong Chen, Lin Zhang, Min Wu, He Xie, Ze-Xiang Guan, Zhe Yang, Zhong-Xian Cai, Jin-Zhou Wen, Li-Ye Yang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Clinical Characteristics and Cytokines of Children With Lower Respiratory Tract Infection Caused by Influenza A After COVID-19.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Fen LinPrecision Medical Lab Center, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou, Guangdong, China.
Man-Tong ChenPrecision Medical Lab Center, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou, Guangdong, China.
Lin ZhangPrecision Medical Lab Center, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou, Guangdong, China.
Min WuDepartment of Pediatrics, People's Hospital of Yangjiang, Yangjiang, Guangdong, China.
He XieDepartment of Pediatrics, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou, Guangdong, China.
Ze-Xiang GuanDepartment of Pediatrics, People's Hospital of Yangjiang, Yangjiang, Guangdong, China.
Zhe YangDepartment of Pediatrics, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou, Guangdong, China.
Zhong-Xian CaiChaozhou Center for Disease Control and Prevention, Chaozhou, Guangdong, China.
Jin-Zhou WenChaozhou Center for Disease Control and Prevention, Chaozhou, Guangdong, China.
Li-Ye YangPrecision Medical Lab Center, People's Hospital of Yangjiang, Yangjiang, Guangdong, China.
Chaozhou Central Hospital · CNPeople's Hospital of Yangzhong · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: The highly infectious Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have caused large-scale transmission from Dec 2022 to Feb 2023 in China. After this event, a remarkable surge of influenza A (Flu A) occurred from March to May 2023, especially in pediatric patients. Objectives: This study aimed to investigate the differences between pediatric patients infected with COVID-19 Omicron and Flu A virus. Methods: A total of 1,063 hospitalized children who admitted into two tertiary general hospital of Guangdong province of China were included. Medical records were compared retrospectively in these patients during the pandemic periods of SARS-CoV-2 omicron and Flu A. Results: A total of 592 Patients with Flu A were mostly preschool and school-aged (>3y, 76.0%), they showed higher ratio of high fever (≥39°C), cough, rhinorrhea, and vomiting than patients with SARS-CoV-2 omicron. Most of the 471 Omicron patients were young children (0-3y, 74.5%) and had more poor appetite and dyspnea symptom. Benign acute children myositis (BACM) was only observed in patients with Flu A, and a significant male predominance. Multisystem inflammatory syndrome in children (MIS-C) was only found in patients with SARS-CoV-2 Omicron. Compared to the SARS-CoV-2 Omicron group, for both age groups (0-3 years and > 3 years), the Flu A group showed significantly reduced lymphocyte (Lym) counts ( Conclusion: Influenza A infections have notably surged in children, coinciding with the relaxation of COVID-19 related social restrictions. During the epidemic periods of Omicron and Flu A virus infection, different clinical and laboratory characteristics were observed in hospitalized children.

Indexed as

benign acute childhood myositis (BACM)clinical featureinfluenza A (Flu A)laboratory indexespediatric patientsSARS-CoV-2 omicron

Identifiers

PMID38274442
PMCPMC10810023
OpenAlexW4390745682

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.