Evidence map›Paper›PMID 38274405›Full record

ArticleiScience2024

Adipose-specific overexpression of human AGPAT2 in mice causes increased adiposity and mild hepatic dysfunction.

Anil K Agarwal, Katie Tunison, Goncalo Vale, Jeffrey G McDonald, Xilong Li, Jay D Horton, Abhimanyu Garg

Open access · goldAbstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. The Role of theInternational journal of molecular sciences · 2025
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Anil K AgarwalSection of Nutrition and Metabolic Diseases, Division of Endocrinology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Katie TunisonSection of Nutrition and Metabolic Diseases, Division of Endocrinology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Goncalo ValeCenter for Human Nutrition, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Jeffrey G McDonaldCenter for Human Nutrition, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Xilong LiPeter O'Donnell Jr. School of Public Health, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Jay D HortonCenter for Human Nutrition, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Abhimanyu GargSection of Nutrition and Metabolic Diseases, Division of Endocrinology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
The University of Texas Southwestern Medical Center · USSouthwestern Medical CenterSouthwestern Medical Center · US

Funding

UT Southwestern Center for Translational MedicineUL1TR003163 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2021 to 2025
$39.3M
Tissue Culture & Antibody Production CoreP01HL160487 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Arun Radhakrishnan · 2022 to 2026
$14.9M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JAY D. HORTON · 2022 to 2026
$7.4M
Genetic and Metabolic Basis of Familial LipodystrophiesR01DK105448 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Abhimanyu Garg · 2015 to 2026
$6.5M
NCATS NIH HHS UL1 TR003163NHLBI NIH HHS P01 HL160487NIDDK NIH HHS P30 DK127984NIDDK NIH HHS R01 DK105448
6 · The paper itself

Abstract

AGPAT2, a critical enzyme involved in the biosynthesis of phospholipids and triacylglycerol (TAG), is highly expressed in adipose tissue (AT). Whether overexpression of AGPAT2 in AT will result in increased TAG synthesis (obesity) and its metabolic complications remains unknown. We overexpressed human

Indexed as

Cell biologyCellular physiologyPhysiology

Identifiers

PMID38274405
PMCPMC10809107
OpenAlexW4389452019

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.