Evidence map›Paper›PMID 38274394›Full record

ArticleJAAD international2024

Adverse events from topical corticosteroid use in chronic hand eczema - Findings from the Danish Skin Cohort.

Alexander Egeberg, Christoph Schlapbach, Jeanette Halskou Haugaard, Lea Nymand, David Thein, Simon Francis Thomsen, Jacob P Thyssen

Open access · goldAbstract read
In one paragraph

Article in JAAD international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. A Practical Approach to Chronic Hand Eczema.Dermatology and therapy · 2025
    Article
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Alexander EgebergDepartment of Dermatology and Venereology, Bispebjerg Hospital, Copenhagen, Denmark.
Christoph SchlapbachDepartment of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Jeanette Halskou HaugaardDepartment of Dermatology and Venereology, Bispebjerg Hospital, Copenhagen, Denmark.
Lea NymandDepartment of Dermatology and Venereology, Bispebjerg Hospital, Copenhagen, Denmark.
David TheinDepartment of Dermatology and Venereology, Bispebjerg Hospital, Copenhagen, Denmark.
Simon Francis ThomsenDepartment of Dermatology and Venereology, Bispebjerg Hospital, Copenhagen, Denmark.
Jacob P ThyssenDepartment of Dermatology and Venereology, Bispebjerg Hospital, Copenhagen, Denmark.
Bispebjerg Hospital · DKUniversity of Copenhagen · DKUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Topical corticosteroids (TCS) are used to treat most patients with chronic hand eczema (CHE), but knowledge about TCS-related adverse events in CHE is limited. Objectives: To investigate patient-reported adverse events to TCS in CHE patients. Methods: Data on adverse events related to TCS use in patients with CHE were analyzed from the Danish Skin Cohort; a prospective survey of a hospital cohort. We assessed patients' knowledge about TCS use and adverse event risks, and preference of TCS versus a nonsteroidal topical alternative. Results: Of 724 adults with CHE (64.0% women; mean age 57.5 [standard deviation 12.8] years), 64.1% reported skin atrophy, 41.4% cracks/fissures, 23.9% bleeding, 45.9% pain/stinging sensation, 40.0% reduced hand dexterity, and 40.2% worsening of CHE signs or symptoms from using TCS. We observed CHE-severity-dependent associations (all groups; Limitations: Differences across TCS formulations were unexplored. Conclusion: TCS-related cutaneous adverse events were common. There is a desire from patients for novel steroid-free topical alternatives for CHE treatment.

Indexed as

adverse eventschronic hand eczemaDanish Skin Cohortside effectstopical corticosteroids

Identifiers

PMID38274394
PMCPMC10808964
OpenAlexW4389285986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.