Evidence map›Paper›PMID 38274349›Full record

ArticleInternational journal for parasitology. Parasites and wildlife2024

Free drug percentage of moxidectin declines with increasing concentrations in the serum of marsupials.

Eliza K Stott, Shuai Nie, Nicholas A Williamson, Lee F Skerratt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal for parasitology. Parasites and wildlife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Eliza K StottOne Health Research Group, Melbourne Veterinary School, Faculty of Science, Werribee, The University of Melbourne, Victoria, Australia.
Shuai NieMelbourne Mass Spectrometry and Proteomics Facility, The University of Melbourne, Victoria, Australia.
Nicholas A WilliamsonMelbourne Mass Spectrometry and Proteomics Facility, The University of Melbourne, Victoria, Australia.
Lee F SkerrattOne Health Research Group, Melbourne Veterinary School, Faculty of Science, Werribee, The University of Melbourne, Victoria, Australia.
The University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Moxidectin (MOX) is a macrocyclic lactone used to eliminate endo and ectoparasites in many mammalian species. It is notably the active ingredient of the anti-parasitic drug Cydectin®, manufactured by Virbac, and is frequently used to treat sarcoptic mange in Australian wildlife. Protein binding plays a significant role in the efficacy of a drug, as the unbound/free drug in plasma ultimately reflects the pharmacologically relevant concentration. This study aimed to investigate the free drug percentage of Moxidectin after

Indexed as

Equilibrium dialysisFree drug percentageLCMSMoxidectinProtein bindingWildlife pharmacology

Identifiers

PMID38274349
PMCPMC10808906
OpenAlexW4390278213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.