ArticleGeneral psychiatry2024
Effects of a periodic intermittent theta burst stimulation in Alzheimer's disease.
Article in General psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04754152 (Long-term Effect of θ Burst Magnetic Stimulation on Clinical Symptoms of Alzheimer Disease), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Long-term Effect of θ Burst Magnetic Stimulation on Clinical Symptoms of Alzheimer Disease
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Effectiveness of noninvasive brain stimulation techniques on cognitive function in individuals with Alzheimer's disease and MCI: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2026Pooled it
- Comparative efficacy of neuromodulation techniques for Alzheimer's disease: a systematic review and network meta-analysis of randomized controlled trials.Frontiers in neuroscience · 2026Pooled it
- Effects of 52 weeks of precuneus rTMS in Alzheimer's disease patients: a randomized trial.Alzheimer's research & therapy · 2025Trial
- Parietal and prefrontal transcranial magnetic stimulation (TMS) for mild cognitive impairment (MCI): A pilot randomized clinical trial.Brain disorders (Amsterdam, Netherlands) · 2026Article
- Non-invasive Neuromodulation Targeting Approach by Mapping Stimulations and Lesions That Modify Visual Memory.bioRxiv : the preprint server for biology · 2026Article
- Transcranial magnetic stimulation mitigates perioperative neurocognitive disorders by regulating the function of the glymphatic system.Cell communication and signaling : CCS · 2026Article
- PyCaret machine learning library with three preprocessing steps after eLORETA source estimation predicts Alzheimer's disease.Neuroimage. Reports · 2026Article
- Plasticity-Induced Motor Recovery of Bilateral Intermittent Theta Burst Stimulation in Parkinson's Disease: A Randomized, Double-Blind, Sham-Controlled, Crossover Trial.Neurology and therapy · 2026Article
- Non-invasive brain stimulation: current and future applications in neurology.Nature reviews. Neurology · 2025Review
- ADAS-Cog Trajectories Differ from Expected Decline in Dementia Following Repeated Non-Invasive Interventions over 3 Years.Medicina (Kaunas, Lithuania) · 2025Article
- Developing a reverse translational model of low-intensity rTMS in alcohol use disorder: The influence of theta burst stimulation protocols on binge alcohol drinking in mice.Transcranial magnetic stimulation (2024) · 2025Article
- Intermittent theta burst stimulation enhances prefrontal activation and connectivity: evidence from fNIRS.Frontiers in human neuroscience · 2025Article
- Preliminary study on the efficacy of intermittent theta burst stimulation (iTBS) in adolescents with affective disorders, with and without antidepressants.General psychiatry · 2025Article
- Open label pilot of personalized, neuroimaging-guided theta burst stimulation in early-stage Alzheimer's disease.Frontiers in neuroscience · 2024Article
- Status and trends of transcranial magnetic stimulation research in Alzheimer's disease: A bibliometric and visual analysis.Journal of Alzheimer's disease reportsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Previous studies have demonstrated that excitatory repetitive transcranial magnetic stimulation (rTMS) can improve the cognitive function of patients with Alzheimer's disease (AD). Intermittent theta burst stimulation (iTBS) is a novel excitatory rTMS protocol for brain activity stimulation with the ability to induce long-term potentiation-like plasticity and represents a promising treatment for AD. However, the long-term effects of iTBS on cognitive decline and brain structure in patients with AD are unknown. Aims: We aimed to explore whether repeating accelerated iTBS every three months could slow down the cognitive decline in patients with AD. Methods: In this randomised, assessor-blinded, controlled trial, iTBS was administered to the left dorsolateral prefrontal cortex (DLPFC) of 42 patients with AD for 14 days every 13 weeks. Measurements included the Montreal Cognitive Assessment (MoCA), a comprehensive neuropsychological battery, and the grey matter volume (GMV) of the hippocampus. Patients were evaluated at baseline and after follow-up. The longitudinal pipeline of the Computational Anatomy Toolbox for SPM was used to detect significant treatment-related changes over time. Results: The iTBS group maintained MoCA scores relative to the control group (t=3.26, p=0.013) and reduced hippocampal atrophy, which was significantly correlated with global degeneration scale changes. The baseline Mini-Mental State Examination (MMSE) score, apolipoprotein E genotype and Clinical Dementia Rating were indicative of MoCA scores at follow-up. Moreover, the GMV of the left (t=0.08, p=0.996) and right (t=0.19, p=0.977) hippocampus were maintained in the active group but significantly declined in the control group (left: t=4.13, p<0.001; right: t=5.31, p Conclusions: DLPFC-iTBS may be a feasible and easy-to-implement non-pharmacological intervention to slow down the progressive decline of overall cognition and quality of life in patients with AD, providing a new AD treatment option. Trial registration number: NCT04754152.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.