Evidence map›Paper›PMID 38274243›Full record

ArticleEuropean journal of obstetrics & gynecology and reproductive biology: X2024

Oxytocin augmentation and neurotransmitters in prolonged delivery: An experimental appraisal.

Antonio Malvasi, Andrea Ballini, Andrea Tinelli, Bernard Fioretti, Antonella Vimercati, Elko Gliozheni, Giorgio Maria Baldini, Eliano Cascardi, Miriam Dellino, Monica Bonetti and 3 more

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In one paragraph

Article in European journal of obstetrics & gynecology and reproductive biology: X, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Antonio MalvasiDepartment of Biomedical Sciences and Human Oncology, University of Bari, 70121 Bari, Italy.
Andrea BalliniDepartment of clinical and experimental medicine, University of Foggia, Foggia, 71122, Italy.
Andrea TinelliDepartment of Obstetrics and Gynecology and CERICSAL (CEntro di RIcerca Clinico SALentino), Veris Delli Ponti Hospital, 73020 Scorrano, Italy.
Bernard FiorettiDepartment of Chemistry, Biology and Biotechnologies, University of Perugia, Via dell'Elce di Sotto 8, 06132 Perugia, Italy.
Antonella VimercatiDepartment of Biomedical Sciences and Human Oncology, University of Bari, 70121 Bari, Italy.
Elko GliozheniSection of Obstetrics and Gynecology, Department of Medicine and Surgery, University of Perugia, 06156 Perugia, Italy.
Giorgio Maria BaldiniMomo Fertilife, IVF Clinic, Bisceglie, 76011, Italy.
Eliano CascardiDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari "Aldo Moro", Policlinico of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy.
Miriam DellinoDepartment of Biomedical Sciences and Human Oncology, University of Bari, 70121 Bari, Italy.
Monica BonettiDepartment of Biomedical Sciences and Human Oncology, University of Bari, 70121 Bari, Italy.
Ettore CicinelliDepartment of Biomedical Sciences and Human Oncology, University of Bari, 70121 Bari, Italy.
Amerigo VitaglianoDepartment of Biomedical Sciences and Human Oncology, University of Bari, 70121 Bari, Italy.
Gianluca Raffaello DamianiDepartment of Biomedical Sciences and Human Oncology, University of Bari, 70121 Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The uterus is a highly innervated organ, and during labor, this innervation is at its highest level. Oxytocinergic fibers play an important role in labor and delivery and, in particular, the Lower Uterine Segment, cervix, and fundus are all controlled by motor neurofibers. Oxytocin is a neurohormone that acts on receptors located on the membrane of the smooth cells of the myometrium. During the stages of labor and delivery, its binding causes myofibers to contract, which enables the fundus of the uterus to act as a mediator. The aim of this study was to investigate the presence of oxytocinergic fibers in prolonged and non-prolonged dystocic delivery in a cohort of 90 patients, evaluated during the first and second stages of labor. Myometrial tissue samples were collected and evaluated by electron microscopy, in order to quantify differences in neurofibers concentrations between the investigated and control cohorts of patients. The authors of this experiment showed that the concentration of oxytocinergic fibers differs between non-prolonged and prolonged dystocic delivery. In particular, in prolonged dystocic delivery, compared to non-prolonged dystocic delivery, there is a lower amount of oxytocin fiber. The increase in oxytocin appeared to be ineffective in patients who experienced prolonged dystocic delivery, since the dystocic labor ended as a result of the altered presence of oxytocinergic fibers detected in this group of patients.

Indexed as

AsynclitismDystociaIntrapartum ultrasoundLower uterine segmentNeurofibersNeurotransmittersOcciput posterior positionOxytocinProlonged labor

Identifiers

PMID38274243
PMCPMC10809121

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.