ArticleFrontiers in plant science2023
Integration of genome-wide association studies, metabolomics, and transcriptomics reveals phenolic acid- and flavonoid-associated genes and their regulatory elements under drought stress in rapeseed flowers.
Article in Frontiers in plant science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Comparative meta-analysis of barely transcriptome: Pathogen type determines host preference.PloS one · 2025Pooled it
- Application of Metabolomics in Defence Responses ofMetabolites · 2026Review
- Roles of Metabolites Unveiled by Metabolomics inMetabolites · 2026Review
- Development and characterization of near-isogenic lines for quantitative trait locus qDT.3B.1 underlying drought tolerance in wheat.The plant genome · 2026Article
- Integrated epigenomic and transcriptional profiling reveals genotype-specific adaptive reprogramming to drought stress in Brassica napus.BMC plant biology · 2026Article
- Ontogenetic regulation of metabolite dynamics inPeerJ · 2026Article
- Exploring metabolite diversity in global rapeseed germplasm: insights into ecotypes, geographical influences, and correlations with diabetes.BMC plant biology · 2025Article
- 2,4-Epibrassinolide Enhances Drought Tolerance inPlants (Basel, Switzerland) · 2025Article
- Evolutionary dynamics and functional divergence of the UDP-glycosyltransferases gene family revealed by a pangenome-wide analysis in tomato.Horticulture research · 2025Article
- Screening tomato genotypes for early-stage drought tolerance using polyethylene glycol-induced osmotic stress.BMC plant biology · 2025Article
- Understanding plant phenotypes in crop breeding through explainable AI.Plant biotechnology journal · 2025Review
- Genome-wide association studies revealed partial genetic links between early vigour and precocity in macadamia.Horticulture research · 2025Article
- An enhanced gene function analysis platform for Gastrodia Elata integrating further omics data and analysis tools.BMC plant biology · 2025Article
- Metabolome integrated with transcriptome, and genome analysis revealed higher accumulations of phytoalexins enhance resistance against Magnaporthe oryzae in new Zhefang rice variety diantun 506.BMC plant biology · 2025Article
- Impact of Geographical Origin on the Contents of Inorganic Elements and Bioactive Compounds inMolecules (Basel, Switzerland) · 2025Article
- Exploring genomic loci and candidate genes associated with drought tolerance indices in spring wheat evaluated under two levels of drought.BMC plant biology · 2025Article
- Genome-wide analysis of CHYR gene family and BnA03.CHYR.1 functional verification under salt stress in Brassica napus L.BMC plant biology · 2025Article
- Article
- The whole-genome dissection of root system architecture provides new insights for the genetic improvement of alfalfa (Horticulture research · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Biochemical and metabolic processes help plants tolerate the adverse effects of drought. In plants accumulating bioactive compounds, understanding the genetic control of the biosynthesis of biochemical pathways helps the discovery of candidate gene (CG)-metabolite relationships. Methods: The metabolic profile of flowers in 119 rapeseed ( Results: In a genome-wide association study (GWAS), of the SNPs tested, 29,310 SNPs were qualified to assess the population structure and linkage disequilibrium (LD), of which several SNPs for radical scavenging activity (RSA) and total flavanol content (TFLC) were common between the two irrigation conditions and pleiotropic SNPs were found for chlorogenic and coumaric acids content. The principal component analysis (PCA) and stepwise regression showed that chlorogenic acid and epicatechin in WW and myricetin in DS conditions were the most important components for RSA. The hierarchical cluster analysis (HCA) showed that vanillic acid, myricetin, gallic acid, and catechin were closely associated in both irrigation conditions. Analysis of GWAS showed that 60 CGs were identified, of which 18 were involved in stress-induced pathways, phenylpropanoid pathway, and flavonoid modifications. Of the CGs, Discussion: These findings expand our knowledge on the response mechanisms to DS, particularly regarding the regulation of key phenolic biosynthetic genes in rapeseed. Our data also provided specific linked SNPs for marker-assisted selection (MAS) programs and CGs as resources toward realizing metabolomics-associated breeding of rapeseed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.