Evidence map›Paper›PMID 38273699›Full record

Observational studyRheumatology (Oxford, England)2025

Thresholds for unacceptable work state in radiographic axial spondyloarthritis of four presenteeism and two clinical outcome measurement instruments.

Dafne Capelusnik, Sofia Ramiro, Elena Nikiphorou, Walter P Maksymowych, Marina Nighat Magrey, Helena Marzo-Ortega, Annelies Boonen

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Rheumatology (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dafne CapelusnikCare and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.ORCID 0000-0001-9336-0416
Sofia RamiroDepartment of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-8899-9087
Elena NikiphorouCentre for Rheumatic Diseases, King's College London, London, UK.
Walter P MaksymowychDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-1291-1755
Marina Nighat MagreyDepartment of Rheumatology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0000-0002-6520-5619
Helena Marzo-OrtegaNIHR Leeds Biomedical Research Centre, LTHT and LIRMM, University of Leeds, Leeds, UK.ORCID 0000-0002-9683-3407
Annelies BoonenCare and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.

Funding

AbbVieBiomedical Research CentreDepartment of HealthNational Health ServiceNational Institute for Health ResearchPfizer and LillyThe AS PROSE
6 · The paper itself

Abstract

objectivesTo (i) identify threshold values of presenteeism measurement instruments that reflect unacceptable work state in employed r-axSpA patients; (ii) determine whether those thresholds accurately predict future adverse work outcomes (AWO) (sick leave or short/long-term disability); (iii) evaluate the performance of traditional health-outcomes for r-axSpA; and (iv) explore whether thresholds are stable across contextual factors.

methodsData from the multinational AS-PROSE study was used. Thresholds to determine whether patients consider themselves in an 'unacceptable work state' were calculated at baseline for four instruments assessing presenteeism and two health outcomes specific for r-axSpA. Different approaches derived from the receiver operating characteristic methodology were used. Validity of the optimal thresholds was tested across contextual factors and for predicting future AWO over 12 months.

resultsOf 366 working patients, 15% reported an unacceptable work state; 6% experienced at least one AWO in 12 months. Optimal thresholds were: WPAI-presenteeism ≥40 (AUC 0.85), QQ-method <97 (0.76), WALS ≥0.75 (AUC 0.87), WLQ-25 ≥ 29 (AUC 0.85). BASDAI and BASFI performed similarly to the presenteeism instruments: ≥4.7 (AUC 0.82) and ≥3.5 (AUC 0.79), respectively. Thresholds for WALS and WLQ-25 were stable across contextual factors, while for all other instruments they overestimated unacceptable work state in lower educated persons. Proposed thresholds could also predict future AWO, although with lower performance, especially for QQ-method, BASDAI and BASFI.

conclusionsThresholds of measurement instruments for presenteeism and health status to identify unacceptable work state have been established. These thresholds can help in daily clinical practice to provide work-related support to r-axSpA patients at risk for AWO.

Indexed as

Axial SpondyloarthritisPresenteeismAdultDisability EvaluationFemaleHumansMaleMiddle AgedOutcome Assessment, Health CareRadiographyROC CurveSick Leavepresenteeismradiographic axial spondyloarthritiswork outcomeswork satisfaction

Identifiers

PMID38273699
PMCPMC11701323

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.