Evidence map›Paper›PMID 38273234›Full record

ArticleBMC infectious diseases2024

Unraveling IL-17 and IL-22 role in occult hepatitis C versus chronic hepatitis C virus infection.

Sherif Elbaz, Nasser Mousa, Alaa Elmetwalli, Ahmed Abdel-Razik, Mohamed Salah, Amr ElHammady, Mostafa Abdelsalam, Eman Abdelkader, Niveen El-Wakeel, Waleed Eldars and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 1 country.

Sherif ElbazEndemic Diseases and Gastroenterology Department, Aswan University, Aswan, Egypt.
Nasser MousaTropical Medicine Department, Mansoura University, Mansoura, Egypt. Mousa_medic@yahoo.com.
Alaa ElmetwalliDepartment of Clinical Trial Research Unit and Drug Discovery, Egyptian Liver Research Institute and Hospital (ELRIAH), Mansoura, Egypt.
Ahmed Abdel-RazikTropical Medicine Department, Mansoura University, Mansoura, Egypt.
Mohamed SalahTropical Medicine Department, Mansoura University, Mansoura, Egypt.
Amr ElHammadyInternal Medicine Department, Banha University, Banha, Egypt.
Mostafa AbdelsalamInternal Medicine Department, Mansoura University, Mansoura, Egypt.
Eman AbdelkaderInternal Medicine Department, Mansoura University, Mansoura, Egypt.
Niveen El-WakeelMedical Microbiology and Immunology Department, Mansoura University, Mansoura, Egypt.
Waleed EldarsMedical Microbiology and Immunology Department, Mansoura University, Mansoura, Egypt.
Ola El-EmamClinical Pathology Department, Mansoura University, Mansoura, Egypt.
Ahmed ElbeltagyClinical Pathology Department, Mansoura University, Mansoura, Egypt.
Mohamed ShaheenClinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Hossam El-ZamekClinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Eman MousaFaculty of Dentistry, Mansoura University, Mansoura, Egypt.
Ahmed DeiabInternal Medicine Department, Mansoura University, Mansoura, Egypt.
Ayman ElgamalDepartment of Tropical Medicine, Menoufia University, Menoufia, Egypt.
Alaa HabibInternal Medicine Department, Mansoura University, Mansoura, Egypt.
Mansoura University · EGAl-Azhar University · EGAswan University · EGBenha University · EGDelta University for Science and Technology · EGMenoufia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCytokines play a crucial role in regulating the function of the immune system by controlling the production, differentiation, and activity of immune cells. Occult hepatitis C virus (OHCV) infection can lead to liver damage, including cirrhosis and hepatocellular carcinoma. This study investigates the immunopathogenic impact of the cytokines IL-17 and IL-22 in OHCV infection compared to chronic hepatitis C (CHC) infection.

methodsWe studied three groups of patients: 35 with OHCV, 100 untreated patients with CHC, and 30 healthy control subjects. All subjects underwent physical examination and biochemical testing. We used the sandwich enzyme-linked immunosorbent assay method to measure serum IL-17 and IL-22 levels in all groups.

resultsCompared to the occult and control groups, the CHC group had significantly higher serum IL-17 levels (p < 0.001). The occult group also had higher serum IL-17 levels compared to the control group (p < 0.0001). There were no significant differences in IL-22 levels across the research groups. In the OHCV group, individuals with moderate inflammation (A2-A3) had significantly higher serum IL-17 levels than those with minimal inflammation (A0-A1), while in the CHC group, this difference was not statistically significant (p = 0.601). Neither the occult nor the CHC groups showed a correlation between serum IL-22 and inflammatory activity. There was no significant correlation between the levels of IL-17 or IL-22 and the stage of fibrosis/cirrhosis in either group. ROC curves were calculated for serum IL-17 and IL-22 levels and occult HCV infection, with cut-off values set at ≤ 32.1 pg/ml and < 14.3 pg/ml for IL-17 and IL-22, respectively. The AUROC (95%CI) was significantly higher for IL-17 than IL-22 (0.829 (0.732-0.902) vs. 0.504 (0.393-0.614), p < 0.001), suggesting that IL-17 has a stronger correlation with infection risk than IL-22.

conclusionThis study suggests that IL-17 may be involved in the immunopathogenesis of OHCV infection, especially in patients with moderate inflammation.

Indexed as

Hepatitis CHepatitis C, ChronicLiver NeoplasmsCytokinesFibrosisHepacivirusHumansInflammationInterleukin-17Interleukin-22Liver CirrhosisCytokinesIL17A protein, humanIL22 protein, humanInterleukin-17Interleukin-22Chronic hepatitis CIL-17IL-22Occult hepatitis C

Identifiers

PMID38273234
PMCPMC10811848
OpenAlexW4391218363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.