ArticleBMC public health2024
Changes in frailty and depressive symptoms among middle-aged and older Chinese people: a nationwide cohort study.
Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Association of oral frailty, social support, and technophobia with depressive symptoms in Chinese older adults with chronic diseases: a cross-sectional study.Scientific reports · 2026Article
- Longitudinal frailty trajectories and risk of incident chronic liver disease among middle-aged and older Chinese adults: the mediating role of depressive symptoms.Research square · 2026Article
- Sleep duration and depressive symptoms among older Chinese adults: a serial mediation model of self-rated health and frailty.BMC geriatrics · 2026Article
- Association of Frailty and Frailty Trajectory with Risk for Respiratory Infectious Diseases.Emerging infectious diseases · 2026Article
- An interpretable machine learning model predicts frailty risk in middle-aged and older adults with gastrointestinal disease: a longitudinal study.Scientific reports · 2026Article
- Inflammation meets insulin resistance: the role of the CRP-triglyceride-glucose index in association with frailty among middle-aged and older adults in China.European journal of medical research · 2026Article
- Grip strength in the association between frailty and new-onset depression in older adults: a multinational longitudinal study.Frontiers in public health · 2026Article
- Prediction Model for Frailty in Middle-Aged and Older Adults with Cardiovascular Disease.Vascular health and risk management · 2026Article
- Associations of changes in frailty with multiple chronic diseases in middle aged and elderly adults.BMC public health · 2025Article
- Higher cardiometabolic index elevates the risk of hyperuricemia in the elderly: findings from the China health and retirement longitudinal study.Annals of medicine · 2025Article
- Association between frailty and cognitive function: a pooled analysis of three ageing cohorts.Translational psychiatry · 2025Article
- Associations between reproductive factors and frailty in middle-aged and older women: evidence from the China health and retirement longitudinal study.Journal of health, population, and nutrition · 2025Article
- Prediction model for depression risk in middle-aged and elderly patients with metabolic syndrome: a nomogram and interpretable machine learning approach based on CHARLS.BMC psychiatry · 2025Article
- Article
- Bidirectional longitudinal associations between estimated muscle mass and self-reported chronic lung disease in middle-aged and older adults: findings from the China health and retirement longitudinal study.BMC public health · 2025Article
- The impact of hearing ability on depression among retired middle-aged and elderly individuals in China: the chain mediating role of self-rated health and life satisfaction.Journal of health, population, and nutrition · 2025Article
- Association of social frailty, sarcopenia, and oral frailty with depressive symptoms in Chinese older adults: a cross-sectional study.BMC public health · 2025Article
- The Interaction Among Depressive Symptoms, Pain, and Frailty in Middle-Aged and Older Adults: A Longitudinal Cross-Lagged Panel Analysis.Depression and anxiety · 2025Article
- Risk factors of frailty/sarcopenia in community older adults: Meta-analysis.Open medicine (Warsaw, Poland) · 2025Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
aimsThe older people bears a severe burden of disease due to frailty and depressive symptoms, however, the results of association between the two in the older Chinese people have been conflicting. Therefore, this study aimed to investigate the developmental trajectories and interactions of frailty and depressive symptoms in the Chinese middle-aged and older adults.
methodsThe study used four waves of data from 2011, 2013, 2015 and 2018 in the China Health and Retirement Longitudinal Study (CHARLS) database, focused on middle-aged and older people ≥ 45 years of age, and analyzed using latent growth models and cross-lagged models.
resultsThe parallel latent growth model showed that the initial level of depressive symptoms had a significant positive predictive effect on the initial level of frailty. The rate of change in depressive symptoms significantly positively predicted the rate of change in frailty. The initial level of frailty had a significant positive predictive effect on the initial level of depressive symptoms, but a significant negative predictive effect on the rate of change in depressive symptoms. The rate of change in frailty had a significant positive predictive effect on the rate of change in depressive symptoms. The results of the cross-lagged analysis indicated a bidirectional causal association between frailty and depressive symptoms in the total sample population. Results for the total sample population grouped by age and gender were consistent with the total sample.
conclusionsThis study recommends advancing the age of concern for frailty and depressive symptoms to middle-aged adults. Both men and women need early screening and intervention for frailty and depressive symptoms to promote healthy aging.
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