Evidence map›Paper›PMID 38273184›Full record

ArticleBiological trace element research2024

Biogenic Selenium Nanoparticles Synthesized by L. brevis 23017 Enhance Aluminum Adjuvanticity and Make Up for its Disadvantage in Mice.

Zheng Zhang, Xinqi De, Weijiao Sun, Runhang Liu, Yifan Li, Zaixing Yang, Ning Liu, Jingyi Wu, Yaxin Miao, Jiaqi Wang and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Biological trace element research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Zheng Zhang *College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Xinqi De *College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Weijiao SunCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Runhang LiuState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Yifan LiCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Zaixing YangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Ning LiuCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Jingyi WuCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Yaxin MiaoCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Jiaqi WangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Fang WangState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China. wangfang06@caas.cn.
Junwei GeCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China. gejunwei@neau.edu.cn.
Northeast Agricultural University · CNChinese Academy of Agricultural Sciences · CNHarbin Veterinary Research Institute · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most popular vaccine adjuvants are aluminum ones, which have significantly reduced the incidence and mortality of many diseases. However, aluminum-adjuvanted vaccines are constrained by their limited capacity to elicit cellular and mucosal immune responses, thus constraining their broader utilization. Biogenic selenium nanoparticles are a low-cost, environmentally friendly, low-toxicity, and highly bioactive form of selenium supplementation. Here, we purified selenium nanoparticles synthesized by Levilactobacillus brevis 23017 (L-SeNP) and characterized them using Fourier-transform infrared spectroscopy, energy-dispersive X-ray spectroscopy, scanning electron microscopy, and transmission electron microscopy. The results indicate that the L-SeNP has a particle size ranging from 30 to 200 nm and is coated with proteins and polysaccharides. Subsequently, we assessed the immune-enhancing properties of L-SeNP in combination with an adjuvant-inactivated Clostridium perfringens type A vaccine using a mouse model. The findings demonstrate that L-SeNP can elevate the IgG and SIgA titers in immunized mice and modulate the Th1/Th2 immune response, thereby enhancing the protective effect of aluminum-adjuvanted vaccines. Furthermore, we observed that L-SeNP increases selenoprotein expression and regulates oxidative stress in immunized mice, which may be how L-SeNP regulates immunity. In conclusion, L-SeNP has the potential to augment the immune response of aluminum adjuvant vaccines and compensate for their limitations in eliciting Th1 and mucosal immune responses.

Indexed as

Adjuvants, ImmunologicNanoparticlesSeleniumAluminumAnimalsClostridium perfringensFemaleMiceMice, Inbred BALB CParticle SizeAdjuvants, ImmunologicAluminumSeleniumAluminum adjuvantsImmunoenhancementLevilactobacillus brevisSelenium nanoparticlesSIgA antibody

Identifiers

PMID38273184
OpenAlexW4391260928

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.