Evidence map›Paper›PMID 38273182›Full record

ArticleJournal of racial and ethnic health disparities2025

Genome-Related Mechanisms Contributing to Differences in Alzheimer's Disease Incidence Between White and Black Older US Adults.

Stanislav Kolpakov, Arseniy Yashkin, Svetlana Ukraintseva, Anatoliy Yashin, Igor Akushevich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of racial and ethnic health disparities, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Stanislav KolpakovSocial Science Research Institute, Duke University, Durham, NC, 27710, USA. stanislav.kolpakov.nikitin@duke.edu.ORCID 0000-0001-6947-8289
Arseniy YashkinSocial Science Research Institute, Duke University, Durham, NC, 27710, USA.
Svetlana UkraintsevaSocial Science Research Institute, Duke University, Durham, NC, 27710, USA.
Anatoliy YashinSocial Science Research Institute, Duke University, Durham, NC, 27710, USA.
Igor AkushevichSocial Science Research Institute, Duke University, Durham, NC, 27710, USA.
Social Science Research Council · US

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
Racial and Geographic Disparities in Risk and Survival of Alzheimer's Disease and Related DementiasR01AG066133 · NIA · DUKE UNIVERSITY · PI AKUSHEVICH, IGOR · 2019 to 2023
$3.7M
Understanding Alzheimer's Disease in the Context of the AgingR01AG062623 · NIA · DUKE UNIVERSITY · PI OUKRAINTSEVA, SVETLANA V. · 2019 to 2023
$3.6M
Genetics of changes in population pyramids: Implications for health forecasting with a focus on Alzheimer's Disease and related dementiasRF1AG046860 · NIA · DUKE UNIVERSITY · PI YASHIN, ANATOLIY I · 2019 to 2019
$3.1M
Determinants of geographic disparities in mortality and multimorbidity in the U.S.R01AG057801 · NIA · DUKE UNIVERSITY · PI AKUSHEVICH, IGOR, KRAUCHANKA, YULIYA · 2019 to 2023
$2.1M
NIA NIH HHS R01 AG057801NIA NIH HHS R01AG057801NIA NIH HHS R01 AG062623NIA NIH HHS R01AG062623NIA NIH HHS R01 AG066133NIA NIH HHS R01AG066133NIA NIH HHS RF1 AG046860NIA NIH HHS RF1AG046860NIA NIH HHS U01 AG009740NIA NIH HHS U01-AG009740U.S. Department of Defense W81XWH-20-1-0253
6 · The paper itself

Abstract

In this manuscript, we leverage a modified GWAS algorithm adapted for use with multidimensional Cox models and data from the Health and Retirement Study to explore how genetic variation influences the size of the disparity in Alzheimer's disease (AD) incidence between older Black and White US adults. We identified four loci that were associated with higher AD incidence levels in older Black adults: (1) rs11077034 (hazard ratio (HR), 4.98) from the RBFOX1 gene; (2) rs7144494 (HR, 1.68) from the HISLA gene; (3) rs7660552 (HR, 3.07) from the SLC25A4 gene; and (4) rs12599485 (HR, 3.181) from the NIP30 gene. The RBFOX1, HISLA, SLC25A4, and NIP30 genes are known to be associated with AD (RBFOX1, NIP30) directly, and also influence the risk of AD risk-related morbidities such as hypertension (RBFOX1, SLC25A4), depression (SLC25A4), and certain cancers (HISLA, SLC25A4). A likely disparity-generating mechanism may lie in endocytosis and abnormal tissue growing mechanisms, depending on inherited gene mutations and the structure of proxies as well as gene-environment interactions with other risk factors such as lifestyle, education level, and access to adequate medical services.

Indexed as

Alzheimer DiseaseBlack or African AmericanHealth Status DisparitiesWhiteAgedAged, 80 and overFemaleGenome-Wide Association StudyHumansIncidenceMaleUnited StatesAlzheimer’sBiostatisticsBlinder-oaxacaDisparityGeneticsGWAS

Identifiers

PMID38273182
PMCPMC11269527
OpenAlexW4391217681

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.