ArticleNature neuroscience2024
Lateral entorhinal cortex subpopulations represent experiential epochs surrounding reward.
Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Distributed cortical learning through LEC-mediated γ-synchrony.Nature communications · 2026Article
- Cross-frequency coordination in a hippocampo-cortical circuit during probabilistic reversal learning.Communications biology · 2026Article
- Coordinating Cognition: The Entorhinal Cortex in Mnemonic, Temporal and Spatial Representation.Cells · 2026Review
- Encoding Patterned Spatial Behavior in the Subiculum.Hippocampus · 2026Review
- Lateral entorhinal cortex supports behaviorally-induced hippocampal ensemble stability for reliable memory recall.bioRxiv : the preprint server for biology · 2026Article
- Behavioral timescale synaptic plasticity: properties, elements and functions.Nature neuroscience · 2026Review
- Dentate Gyrus Engrams in Fear and Reward: Mechanistic Principles, Critical Gaps, and Paths to Translation.Journal of neurochemistry · 2026Review
- Temporal Coding rather than Circuit Wiring allows Hippocampal CA3 Neurons to Dynamically Distinguish Different Cortical Inputs.bioRxiv : the preprint server for biology · 2026Article
- Hierarchical Distribution of Reward Representation in the Cortical and Hippocampal Regions.eNeuro · 2026Article
- The perforant pathway and CA3-Schaffer collateral afferents coordinate to regulate spatial learning.Communications biology · 2026Article
- Environmental enrichment accelerates the stabilization of cortical representation duringiScience · 2026Article
- A predictive map learned from diverse entorhinal inputs explains the role of context-dependent reorganization of hippocampal place cells.Frontiers in computational neuroscience · 2026Article
- Oxytocin specifically participates in social memory encoding by exciting stellate neurons in the lateral entorhinal cortex.Frontiers in behavioral neuroscience · 2026Article
- The Optically Guided and Pre-assembled Implantation Cranial Window Reveals Cortical Spatial Representations during Navigation.Research (Washington, D.C.) · 2026Article
- Composing egocentric and allocentric maps for flexible navigation.PLoS computational biology · 2026Article
- Activation of the medial entorhinal cortex drives memory-guided navigation behavior.bioRxiv : the preprint server for biology · 2025Article
- Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability.Science (New York, N.Y.) · 2025Article
- Modulation of speed-dependent acetylcholine release in the hippocampus by spatial task engagement.Cell reports · 2025Article
- Distinct brain regions map olfactory and visual spaces.bioRxiv : the preprint server for biology · 2025Article
- Environmental enrichment accelerates cortical memory consolidation.bioRxiv : the preprint server for biology · 2025Article
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Abstract
During goal-directed navigation, 'what' information, describing the experiences occurring in periods surrounding a reward, can be combined with spatial 'where' information to guide behavior and form episodic memories. This integrative process likely occurs in the hippocampus, which receives spatial information from the medial entorhinal cortex; however, the source of the 'what' information is largely unknown. Here, we show that mouse lateral entorhinal cortex (LEC) represents key experiential epochs during reward-based navigation tasks. We discover separate populations of neurons that signal goal approach and goal departure and a third population signaling reward consumption. When reward location is moved, these populations immediately shift their respective representations of each experiential epoch relative to reward, while optogenetic inhibition of LEC disrupts learning the new reward location. Therefore, the LEC contains a stable code of experiential epochs surrounding and including reward consumption, providing reward-centric information to contextualize the spatial information carried by the medial entorhinal cortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.