ArticleNature communications2024
Revisiting the Plasmodium sporozoite inoculum and elucidating the efficiency with which malaria parasites progress through the mosquito.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Article
- Protective near-germline antibodies to malaria elicited by RTS,S/AS01bioRxiv : the preprint server for biology · 2026Article
- Equitable access to monoclonal antibodies targeting parasites.Trends in parasitology · 2026Review
- Host cell traversal by Plasmodium parasites drives sterilizing T cell-mediated immunity following immunization.Nature microbiology · 2026Article
- Plasmodium falciparum sporozoite loads in Anopheles gambiae s.l. across agro-ecological zones of Benin: a cross-sectional field study.Tropical medicine and health · 2026Article
- Changing Species Dynamics and Species-Specific Associations Observed between Anopheles and Plasmodium Genera in Diebougou Health District, Southwest Burkina Faso.The American journal of tropical medicine and hygiene · 2026Article
- Expelling of Plasmodium falciparum Sporozoites by Anopheles stephensi Mosquitoes During Repeated Feeding.The Journal of infectious diseases · 2026Article
- Genetic control of malaria transmission: a salivary gland-centric perspective.Current opinion in insect science · 2026Review
- The Putative E3 Ubiquitin Ligase TEX1 Is Required for Nuclear Biology and Developmental Progression ofCells · 2026Article
- Evaluation ofiScience · 2025Article
- Unusual replication dynamics during Plasmodium falciparum schizogony.Malaria journal · 2025Review
- High-resolution proteomics unveils salivary gland disruption and saliva-hemolymph protein exchange in Plasmodium-infected mosquitoes.Nature communications · 2025Article
- Degradation of ribosomal RNA duringmBio · 2025Article
- Influence of biophysical and biochemical cues on Plasmodium sporozoite dynamics in skin tissue.Parasites & vectors · 2025Review
- Spatial and temporal distribution of four malaria vector species and their relative contributions to Plasmodium falciparum transmission along the south-north transect of Benin, West Africa.Tropical medicine and health · 2025Article
- Article
- Anopheles mosquito exposure is associated with age, gender and bed net use in areas in Uganda experiencing varying malaria transmission intensity.The Journal of infection · 2025Article
- Targeting Bottlenecks in Malaria Transmission: Antibody-Epitope Descriptions Guide the Design of Next-Generation Biomedical Interventions.Immunological reviews · 2025Review
- Advances in the dissection of Anopheles-Plasmodium interactions.PLoS pathogens · 2025Review
- Impact of the intensity of infection in birds on Plasmodium development within Culex pipiens mosquitoes.Parasites & vectors · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Malaria is initiated when infected anopheline mosquitoes inoculate sporozoites as they probe for blood. It is thought that all infected mosquitoes are equivalent in terms of their infectious potential, with parasite burden having no role in transmission success. In this study, using mosquitoes harboring the entire range of salivary gland sporozoite loads observed in the field, we demonstrate a strong and highly significant correlation between mosquito parasite burden and inoculum size. We then link the inoculum data to oocyst counts, the most commonly-used metric to assess mosquito infection in the field, and determine the efficiency with which oocyst sporozoites enter mosquito salivary glands. Taken together our data support the conclusion that mosquitoes with higher parasite burdens are more likely to initiate infection and contribute to onward transmission. Overall these data may account for some of the unexplained heterogeneity in transmission and enable more precise benchmarks for transmission-blocking interventions.
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