ArticleNature communications2024
A developmental increase of inhibition promotes the emergence of hippocampal ripples.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- Developmental CA2 perineuronal net reduction restores social memory in Shank3 mutant mice.Communications biology · 2026Article
- Brain complexity in response to auditory stimulation improves evaluation of cerebral maturation in premature newborns.Pediatric research · 2026Article
- Developmental CA2 perineuronal net reduction restores social memory inbioRxiv : the preprint server for biology · 2025Article
- Compensatory Regulation of Excitation/Inhibition Balance in the Ventral Hippocampus: Insights from Fragile X Syndrome.Biology · 2025Review
- Pallidal prototypic neuron and astrocyte activities regulate flexible reward-seeking behaviors.bioRxiv : the preprint server for biology · 2025Article
- The gamma rhythm as a guardian of brain health.eLife · 2024Review
- Development of Prefrontal Circuits and Cognitive Abilities.Cold Spring Harbor perspectives in biology · 2024Review
- Synchronous excitation in the superficial and deep layers of the medial entorhinal cortex precedes early sharp waves in the neonatal rat hippocampus.Frontiers in cellular neuroscience · 2024Article
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Authors and funding
5 authors.
Funding
Abstract
Sharp wave-ripples (SPW-Rs) are a hippocampal network phenomenon critical for memory consolidation and planning. SPW-Rs have been extensively studied in the adult brain, yet their developmental trajectory is poorly understood. While SPWs have been recorded in rodents shortly after birth, the time point and mechanisms of ripple emergence are still unclear. Here, we combine in vivo electrophysiology with optogenetics and chemogenetics in 4 to 12-day-old mice to address this knowledge gap. We show that ripples are robustly detected and induced by light stimulation of channelrhodopsin-2-transfected CA1 pyramidal neurons only from postnatal day 10 onwards. Leveraging a spiking neural network model, we mechanistically link the maturation of inhibition and ripple emergence. We corroborate these findings by reducing ripple rate upon chemogenetic silencing of CA1 interneurons. Finally, we show that early SPW-Rs elicit a more robust prefrontal cortex response than SPWs lacking ripples. Thus, development of inhibition promotes ripples emergence.
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