Evidence map›Paper›PMID 38272364›Full record

ArticleJournal of affective disorders2024

Medically unexplained pain and suicidal ideation among US adults.

Ashley Redding, Viktoryia A Kalesnikava, Rachel Bergmans, Stephen Redding, Kallisse Dent, Briana Mezuk

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Suicidal ideation and medical comorbidity: a hidden problem.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ashley ReddingPublic Health Sciences, Henry Ford Health, Detroit, MI 48202, United States of America.
Viktoryia A KalesnikavaCenter for Social Epidemiology and Population Health, University of Michigan School of Public Health, Ann Arbor, MI 48109, United States of America.
Rachel BergmansEisenberg Family Depression Center, University of Michigan, Ann Arbor, MI 48109, United States of America.
Stephen ReddingWayne State University School of Medicine, Detroit, MI 48201, United States of America.
Kallisse DentDepartment of Psychology, University of Michigan, Ann Arbor, MI 48109, United States of America.
Briana MezukCenter for Social Epidemiology and Population Health, University of Michigan School of Public Health, Ann Arbor, MI 48109, United States of America; Eisenberg Family Depression Center, University of Michigan, Ann Arbor, MI 48109, United States of America. Electronic address: bmezuk@umich.edu.
University of Michigan–Ann Arbor · USHenry Ford Health System · USWayne State University · US

Funding

EPIDEMIOLOGY-- NATIONAL COMORBIDITY SURVEY REPLICATIONU01MH060220 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI KESSLER, RONALD C · 1999 to 2010
$18.7M
Diversity Supplement: Aging, Major Life Transitions, and Suicide RiskR01MH128198 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Briana Mezuk, Kara Zivin · 2022 to 2026
$3.9M
Interdisciplinary Research Training on Health and AgingT32AG027708 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lindsay C Kobayashi, Briana Mezuk · 2008 to 2026
$2.7M
HSRD VA IK6 HX003397NIA NIH HHS T32 AG027708NIA NIH HHS T32 AG027709NIMH NIH HHS R01 MH128198NIMH NIH HHS U01 MH060220
6 · The paper itself

Abstract

backgroundChronic pain is an established risk factor for suicide. Pain syndromes are complex to diagnose, particularly in cases with limited evidence of injury or pathology. The goal of this study is to assess whether pain of unknown origin (i.e., medically-unexplained pain, MUEP) is more strongly associated with suicide behaviors than pain with a diagnostic explanation.

methodsData comes from the National Comorbidity Survey-Replication, a nationally-representative sample of US adults. Analysis was limited to participants with a lifetime history of any type of chronic pain (n = 3421), which were categorized as having medically-explained pain (MEP, e.g., pain due to a specific health condition or resulting from an injury identified in an x-ray) or MUEP. Logistic regression, using survey procedures, was used to assess the relationship between lifetime MUEP and lifetime history of suicidal ideation and attempts.

resultsApproximately 1 in 10 (11.6 %) adults with chronic pain had MUEP. Those with MUEP reported earlier age of pain onset and more impairment due to health problems. Suicidal ideation was reported by 18.7 % of those with MEP and 28.4 % of those with MUEP. In fully-adjusted models, MUEP was associated with 1.60 times (95 % CI: 1.17-2.18) higher odds of suicidal ideation, and 1.89 (1.25-2.83) higher odds of suicide attempt, compared to MEP. LIMITATIONS: Cross-sectional analysis; MUEP assessed by self-report.

conclusionsAmong adults with chronic pain, those with MUEP are more likely to report suicide behaviors. Findings illustrate a role for diagnostic and treatment processes in the relationship between pain and suicide.

Indexed as

Chronic PainSuicidal IdeationAdultComorbidityCross-Sectional StudiesHumansRisk FactorsSuicide, AttemptedChronic painDiagnosisEpidemiologyPublic healthSuicide

Identifiers

PMID38272364
PMCPMC11444247
OpenAlexW4391127443

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.