Evidence map›Paper›PMID 38272119›Full record

ArticleJournal of substance use and addiction treatment2024

Timing of treatment for opioid use disorder among birthing people.

Kyungha Kim, Guodong Liu, Andrew W Dick, Sung W Choi, Edeanya Agbese, Tammy E Corr, Charleen Hsuan, Megan S Wright, Sujeong Park, Diana Velott and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of substance use and addiction treatment, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
4.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Neonatal outcomes after antenatal medication for opioid use disorder.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Kyungha KimDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA. Electronic address: kyunghakim@rx.umaryland.edu.
Guodong LiuDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.
Andrew W DickRAND Corporation, Boston, MA, USA.
Sung W ChoiSchool of Public Affairs, The Pennsylvania State University, Harrisburg, PA, USA.
Edeanya AgbeseDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.
Tammy E CorrDepartment of Pediatrics, Penn State Milton S. Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USA.
Charleen HsuanDepartment of Health Policy and Administration, The Pennsylvania State University, University Park, PA, USA.
Megan S WrightDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA; Penn State Law, University Park, PA, USA; Department of Humanities, Penn State College of Medicine, Hershey, PA, USA.
Sujeong ParkSchool of Public Affairs, The Pennsylvania State University, Harrisburg, PA, USA.
Diana VelottDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.
Douglas L LeslieDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.
Pennsylvania State University · USPennsylvania Department of Agriculture · USPenn State Milton S. Hershey Medical Center · USRAND Corporation · US

Funding

The effects of state policies on opioid use disorders in pregnant women: prevalence, treatment and outcomesR01HS026917 · AHRQ · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LESLIE, DOUGLAS L. · 2019 to 2021
$1.2M
AHRQ HHS R01 HS026917
6 · The paper itself

Abstract

backgroundThe number of pregnant women with opioid use disorder (OUD) has increased over time. Although effective treatment options exist, little is known about the extent to which women receive treatment during pregnancy and at what stage of pregnancy care is initiated.

methodsUsing a national private health insurance claims database, we identified women aged 13-49 who gave birth in 2006-2019 and had an OUD or nonfatal opioid overdose (NFOO) diagnosis during the year prior to or at delivery. We then identified women who received their first OUD treatment prior to or during pregnancy. In this cross-sectional study, we investigated how rates and timing of the initial OUD treatment changed over time. Furthermore, we examined factors associated with early initiation of OUD treatment among birthing people.

resultsOf the 7057 deliveries from 6747 women with OUD or NFOO, 63.3 % received any OUD treatment. Rates of OUD treatment increased from 42.9 % in 2006 to 69 % in 2019. Of those treated, in 2006, 54.5 % received their first treatment prior to conception and 24.2 % initiated care during the 1st trimester. In 2019, 68.9 % received their first treatment prior to conception, and 15.1 % initiated care during the 1st trimester. The percentage of women who were first treated in the 2nd trimester or later decreased from 21.2 % in 2006 to 16.1 % in 2019. Factors associated with early treatment initiation include being 25 years or older (age 25-34: aOR, 1.51, 95 % CI, 1.28-1.78; age 35-49: aOR, 1.82, 95 % CI, 1.39-2.37), living in urban areas (aOR, 1.28; 95 % CI, 1.05-1.56), having pre-existing behavioral health comorbidities such as anxiety disorders (aOR, 1.8; 95 % CI, 1.40-2.32), mood disorders (aOR, 1.63; 95 % CI, 1.02-2.61), and substance use disorder other than OUD (aOR, 2.56; 95 % CI, 2.03-3.32).

conclusionOverall, rates of OUD treatment increased over time, and more women initiated OUD treatment prior to conception. Despite these improvements, over one-third of pregnant women with OUD/NFOO either received no treatment or did not initiate care until the 3rd trimester in 2019. Future research should examine barriers to OUD treatment initiation among pregnant women.

Indexed as

Opioid-Related DisordersAdolescentAdultCross-Sectional StudiesFemaleHumansMiddle AgedOpiate OverdoseOpiate Substitution TreatmentPregnancyPregnancy ComplicationsTime FactorsTime-to-TreatmentYoung AdultBuprenorphineMedication for Opioid Use Disorder (MOUD)Opioid use disorder (OUD)PregnancyTiming of OUD treatment initiation

Identifiers

PMID38272119
PMCPMC11090704
OpenAlexW4391168420

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.