Evidence map›Paper›PMID 38272107›Full record

ArticlePhysiology & behavior2024

Characterizing a new tool to manipulate area postrema GLP1R

Stephanie Fulton, Charles C Horn, Chuchu Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiology & behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Stephanie FultonUPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Charles C HornUPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Chuchu ZhangDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: chuchuzhang@mednet.ucla.edu.
University of California, Los Angeles · USUniversity of Pittsburgh · USUPMC Hillman Cancer Center · US

Funding

Molecular and circuit mechanisms of nausea-associated behaviorsR00NS129758 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, CHUCHU · 2023 to 2025
$813k
Optogenetic control of vagal afferent signaling in chemotherapy-induced nausea and emesisR03CA201962 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HORN, CHARLES CHRISTOPHER · 2016 to 2017
$155k
NCI NIH HHS R03 CA201962NINDS NIH HHS R00 NS129758
6 · The paper itself

Abstract

Nausea is an uncomfortable sensation that accompanies many therapeutics, especially diabetes treatments involving glucagon-like peptide-1 receptor (GLP1R) agonists. Recent studies in mice have revealed that GLP1R-expressing neurons in the area postrema play critical roles in nausea. Here, we characterized a ligand-conjugated saporin that can efficiently ablate GLP1R

Indexed as

Area PostremaGlucagon-Like Peptide-1 ReceptorAnimalsHumansMiceNauseaNeuronsShrewsVomitingGlucagon-Like Peptide-1 ReceptorArea postremaEmesisGLP1RNauseaShrew

Identifiers

PMID38272107
PMCPMC11184917
OpenAlexW4391130573

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.