Evidence map›Paper›PMID 38271963›Full record

ArticleAnimal bioscience2024

Effects of stocking density on the homeostasis of uric acid and related liver and kidney functions in ducks.

Peiyi Lin, Sui Liufu, Jinhui Wang, Zhanpeng Hou, Yu Liang, Haiyue Wang, Bingxin Li, Nan Cao, Wenjun Liu, Yunmao Huang and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animal bioscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Peiyi LinCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Sui LiufuCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Jinhui WangCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Zhanpeng HouCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Yu LiangCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Haiyue WangCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Bingxin LiCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Nan CaoCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Wenjun LiuCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Yunmao HuangCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Yunbo TianCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Danning XuCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Xiujin LiCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Xinliang FuCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Zhongkai University of Agriculture and Engineering · CN

Funding

APC 2021A1515111167Guangdong Basic and Applied Basic Research Foundation 2021A1515111167Modern Agriculture Waterfowl Industry Technology System Innovation Team of Guangdong 2022KJ137
6 · The paper itself

Abstract

objectiveStocking density (SD) is an important issue in the poultry industry, which is related to the production performance, intestinal health and immune status. In the present study, the effects of SD on the metabolism and homeostasis of uric acid as well as the related functions of the liver and kidney in ducks were examined.

methodsA total of 360 healthy 56-day-old Shan-ma ducks were randomly divided into the low stocking density (n = 60, density = 5 birds/m2), medium stocking density (n = 120, density = 10 birds/m2) and high stocking density groups (HSD; n = 180, density = 15 birds/m2). Samples were collected in the 3rd, 6th, and 9th weeks of the experiment for analysis.

resultsThe serum levels of uric acid, lipopolysaccharide and inflammatory cytokines (interleukin-1β [IL-1β], IL-8, and tumor necrosis factor-α [TNF-α]) were increased significantly in the HSD group. Serious histopathological lesions could be seen in both the livers and kidneys in the HSD group in the 9th week. The mRNA expression levels of inflammatory cytokines (IL-8 and TNF-α) and related pathway components (toll-like receptor 4, myeloid differentiation primary response gene 88, and nuclear factor-κB) were increased significantly in both the livers and kidneys in the HSD group. The mRNA expression levels of enzymes (adenosine deaminase, xanthine oxidase, phosphoribosyl pyrophosphate amidotransferase, and phosphoribosyl pyrophosphate synthetase 1) related to the synthesis of uric acid increased significantly in the livers in the HSD group. However, the mRNA expression level of solute carrier family 2 member 9, which plays an important role in the excretion of uric acid by the kidney, was decreased significantly in the kidneys in the HSD group.

conclusionThese results indicated that a higher SD could cause tissue inflammatory lesions in the liver and kidney and subsequently affect the metabolism and homeostasis of uric acid, and is helpful for guiding decisions related to the breeding and production of ducks.

Indexed as

HyperuricemiaInflammatory LesionsStocking DensityUric Acid

Identifiers

PMID38271963
PMCPMC11065707
OpenAlexW4391050613

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.