Evidence map›Paper›PMID 38271748›Full record

ReviewCurrent opinion in microbiology2024

Exploring the transcriptional landscape of phage-host interactions using novel high-throughput approaches.

Leena Putzeys, Laura Wicke, Ana Brandão, Maarten Boon, Diana P Pires, Joana Azeredo, Jörg Vogel, Rob Lavigne, Milan Gerovac

Open access · hybridAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Leena PutzeysDepartment of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven, Belgium.
Laura WickeDepartment of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven, Belgium; Institute for Molecular Infection Biology (IMIB), Medical Faculty, University of Würzburg, Würzburg, Germany.
Ana BrandãoCentre of Biological Engineering, University of Minho, Braga, Portugal.
Maarten BoonDepartment of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven, Belgium.
Diana P PiresCentre of Biological Engineering, University of Minho, Braga, Portugal.
Joana AzeredoCentre of Biological Engineering, University of Minho, Braga, Portugal.
Jörg VogelInstitute for Molecular Infection Biology (IMIB), Medical Faculty, University of Würzburg, Würzburg, Germany; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany.
Rob LavigneDepartment of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven, Belgium.
Milan GerovacInstitute for Molecular Infection Biology (IMIB), Medical Faculty, University of Würzburg, Würzburg, Germany; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany. Electronic address: milan.gerovac@uni-wuerzburg.de.
KU Leuven · BEUniversity of Minho · PTUniversity of Würzburg · DE

Funding

European Research Council
6 · The paper itself

Abstract

In the last decade, powerful high-throughput sequencing approaches have emerged to analyse microbial transcriptomes at a global scale. However, to date, applications of these approaches to microbial viruses such as phages remain scarce. Tailoring these techniques to virus-infected bacteria promises to obtain a detailed picture of the underexplored RNA biology and molecular processes during infection. In addition, transcriptome study of stress and perturbations induced by phages in their infected bacterial hosts is likely to reveal new fundamental mechanisms of bacterial metabolism and gene regulation. Here, we provide references and blueprints to implement emerging transcriptomic approaches towards addressing transcriptome architecture, RNA-RNA and RNA-protein interactions, RNA modifications, structures and heterogeneity of transcription profiles in infected cells that will provide guides for future directions in phage-centric therapeutic applications and microbial synthetic biology.

Indexed as

BacteriophagesBacteriaGene Expression RegulationRNATranscriptomeRNA

Identifiers

PMID38271748
PMCPMC10884466
OpenAlexW4391209317

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.