Evidence map›Paper›PMID 38271668›Full record

ArticleJournal of the American Chemical Society2024

Uridine Bisphosphonates Differentiate Phosphoglycosyl Transferase Superfamilies.

Leah M Seebald, Pouya Haratipour, Michaela R Jacobs, Hannah M Bernstein, Boris A Kashemirov, Charles E McKenna, Barbara Imperiali

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Leah M SeebaldDepartment of Biology and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.ORCID 0000-0001-8890-8985
Pouya HaratipourDepartment of Chemistry, University of Southern California, Los Angeles, California 90089, United States.ORCID 0000-0003-0181-8958
Michaela R JacobsDepartment of Chemistry, University of Southern California, Los Angeles, California 90089, United States.ORCID 0009-0005-6063-5010
Hannah M BernsteinDepartment of Biology and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Boris A KashemirovDepartment of Chemistry, University of Southern California, Los Angeles, California 90089, United States.
Charles E McKennaDepartment of Chemistry, University of Southern California, Los Angeles, California 90089, United States.ORCID 0000-0002-3540-6663
Barbara ImperialiDepartment of Biology and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.ORCID 0000-0002-5749-7869
University of Southern California · USMassachusetts Institute of Technology · US

Funding

SPECIFICITY IN CO- AND POST-TRANSLATIONAL MODIFICATIONR01GM039334 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ALLEN, KAREN N., IMPERIALI, BARBARA · 1993 to 2025
$8.0M
Structure and function of the monotopic phosphoglycosyl transferase superfamily: Initiators of biosynthesis of complex bacterial glycoconjugatesR01GM131627 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ALLEN, KAREN N. · 2019 to 2025
$3.1M
NIGMS NIH HHS R01 GM039334NIGMS NIH HHS R01 GM131627
6 · The paper itself

Abstract

Complex bacterial glycoconjugates drive interactions between pathogens, symbionts, and their human hosts. Glycoconjugate biosynthesis is initiated at the membrane interface by phosphoglycosyl transferases (PGTs), which catalyze the transfer of a phosphosugar from a soluble uridine diphosphosugar (UDP-sugar) substrate to a membrane-bound polyprenol-phosphate (Pren-P). The two distinct superfamilies of PGT enzymes (polytopic and monotopic) show striking differences in their structure and mechanism. We designed and synthesized a series of uridine bisphosphonates (UBPs), wherein the diphosphate of the UDP and UDP-sugar is replaced by a substituted methylene bisphosphonate (CXY-BPs; X/Y = F/F, Cl/Cl, (

Indexed as

DiphosphatesTransferasesDiphosphonatesGlycoconjugatesHumansSugarsUridineUridine DiphosphateDiphosphatesDiphosphonatesGlycoconjugatesSugarsTransferasesUridineUridine Diphosphate

Identifiers

PMID38271668
PMCPMC10922802
OpenAlexW4391213981

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.