Evidence map›Paper›PMID 38271597›Full record

ReviewJournal of industrial microbiology & biotechnology2024

One-pot chemoenzymatic syntheses of non-canonical amino acids.

Tsung-Han Chao, Xiangyu Wu, Hans Renata

Abstract readReview
In one paragraph

Review in Journal of industrial microbiology & biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Expedient Synthesis ofJournal of the American Chemical Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tsung-Han ChaoDe partment of Chemistry, BioScience Research Collaborative, Rice University, Houston, TX 77005, USA.
Xiangyu WuDe partment of Chemistry, BioScience Research Collaborative, Rice University, Houston, TX 77005, USA.
Hans RenataDe partment of Chemistry, BioScience Research Collaborative, Rice University, Houston, TX 77005, USA.ORCID 0000-0003-2468-2328

Funding

Biocatalytic C-H Functionalization Logic in the Chemoenzymatic Synthesis of Therapeutic Natural ProductsR35GM128895 · NIGMS · UNIVERSITY OF FLORIDA · PI Hans Renata · 2018 to 2026
$3.7M
NIGMS NIH HHS R35 GM128895NIH HHS R35 GM128895
6 · The paper itself

Abstract

Despite their prevalent use in drug discovery and protein biochemistry, non-canonical amino acids are still challenging to synthesize through purely chemical means. In recent years, biocatalysis has emerged as a transformative paradigm for small-molecule synthesis. One strategy to further empower biocatalysis is to use it in combination with modern chemical reactions and take advantage of the strengths of each method to enable access to challenging structural motifs that were previously unattainable using each method alone. In this Mini-Review, we highlight several recent case studies that feature the synergistic use of chemical and enzymatic transformations in one pot to synthesize novel non-canonical amino acids. ONE-SENTENCE SUMMARY: This Mini-Review highlights several recent case studies that feature the synergistic use of chemical and enzymatic transformations in one pot to synthesize novel non-canonical amino acids.

Indexed as

AminesAmino AcidsBiocatalysisAminesAmino AcidsBiocatalysisChemoenzymaticNon-canonical amino acidOxidationPLP

Identifiers

PMID38271597
PMCPMC10853765

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.