Evidence map›Paper›PMID 38271521›Full record

ArticleScience (New York, N.Y.)2024

Changing fitness effects of mutations through long-term bacterial evolution.

Alejandro Couce, Anurag Limdi, Melanie Magnan, Siân V Owen, Cristina M Herren, Richard E Lenski, Olivier Tenaillon, Michael Baym

Open access · hybridAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
36.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 70 citations in OpenAlex.

  1. Review
  2. Article
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  4. Article
  5. Article
  6. Article
  7. Article
  8. Structural and evolutionary constraints of organophosphate resistance in dipteran carboxylesterases.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. The evolution of genetic drift over 50,000 generations.bioRxiv : the preprint server for biology · 2026
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Ecological diversification in rapidly evolving populations.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Alejandro Couce *Université Paris Cité and Université Sorbonne Paris Nord, Inserm, IAME, F-75018 Paris, France.ORCID 0000-0002-4153-6018
Anurag Limdi *Department of Biomedical Informatics, and Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4891-8254
Melanie MagnanUniversité Paris Cité and Université Sorbonne Paris Nord, Inserm, IAME, F-75018 Paris, France.ORCID 0000-0003-0295-2489
Siân V OwenDepartment of Biomedical Informatics, and Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-5330-3177
Cristina M HerrenDepartment of Biomedical Informatics, and Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-5672-7506
Richard E LenskiDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-1064-8375
Olivier Tenaillon *Université Paris Cité and Université Sorbonne Paris Nord, Inserm, IAME, F-75018 Paris, France.ORCID 0000-0002-3796-1601
Michael Baym *Department of Biomedical Informatics, and Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-1303-5598
Harvard University · USInserm · FRMichigan State University · USNortheastern University · US

Funding

Evolutionary Tradeoffs in Antibiotic ResistanceR35GM133700 · NIGMS · HARVARD MEDICAL SCHOOL · PI BAYM, MICHAEL · 2019 to 2023
$2.4M
NIGMS NIH HHS R35 GM133700
6 · The paper itself

Abstract

The distribution of fitness effects of new mutations shapes evolution, but it is challenging to observe how it changes as organisms adapt. Using

Indexed as

Escherichia coliEvolution, MolecularGenetic FitnessAdaptation, PhysiologicalMutagenesis, InsertionalMutationSelection, Genetic

Identifiers

PMID38271521
PMCPMC13327790
OpenAlexW4391215112

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.