SynthesisAmerican journal of respiratory and critical care medicine2024
Effectiveness of Fludrocortisone Plus Hydrocortisone versus Hydrocortisone Alone in Septic Shock: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.
Open access · greenAbstract readSystematic ReviewComparative StudyNetwork Meta-Analysis
In one paragraph
Synthesis in American journal of respiratory and critical care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
12.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Hydrocortisone combined with fludrocortisone for treatment of adults with septic shock: an updated meta-analysis and systematic review.Frontiers in medicine · 2026Pooled it
- Efficacy and safety of corticosteroids in critically ill patients: a systematic review and meta-analysis.BMC anesthesiology · 2025Pooled it
- Corticosteroids for treating sepsis in children and adults.The Cochrane database of systematic reviews · 2025Pooled it
- Mineralocorticoid magic? Evaluating fludrocortisone in septic shock.British journal of clinical pharmacology · 2026Review
- Hydrocortisone Use for Septic Shock in Patients With CKD.Kidney international reports · 2026Article
- A clinician's guide to corticosteroid therapy in pneumonia and critical illness: agent selection, dosing, monitoring, and interactions.Pneumonia (Nathan Qld.) · 2026Review
- Article
- Use of corticosteroids in sepsis and infectious diseases: a narrative review.The Korean journal of internal medicine · 2026Review
- Optimization of glucocorticoid administration in patients with sepsis using reinforcement learning: a multicenter retrospective study.Frontiers in cellular and infection microbiology · 2026Article
- Machine learning identifies clinical sepsis phenotypes that translate to the plasma proteome.Infection · 2025Article
- Xuebijing injection reduces 28-day mortality in patients with septic shock.Critical care (London, England) · 2025Article
- A double-edged sword: a narrative review on steroids in sepsis and septic shock.Internal and emergency medicine · 2025Review
- Current corticosteroid therapeutic strategy for community-acquired pneumonia in adults: indications, dosage, and timing.Journal of intensive care · 2025Review
- Effect of methylprednisolone vs hydrocortisone on 30-day mortality in critically ill adults with septic shock: an analysis of the MIMIC-IV database.BMC infectious diseases · 2025Article
- [What is confirmed in the treatment of sepsis? : An update].Innere Medizin (Heidelberg, Germany) · 2024Review
- Fludrocortisone with hydrocortisone in sepsis: new evidence in an ongoing debate.Intensive care medicine · 2024Article
- Mineralocorticoid Receptor and Sleep Quality in Chronic Kidney Disease.International journal of molecular sciences · 2024Review
- [Therapeutic effects of glucocorticoids in patients with hematologic diseases with neutropenia and severe pneumonia classified by the PSI scores].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2024Article
- Reply to Yoshihiro and Taito: True Effect of Fludrocortisone for Septic Shock: Baseline Risk and Transitivity Concerns.American journal of respiratory and critical care medicine · 2024Article
- True Effect of Fludrocortisone for Septic Shock: Baseline Risk and Transitivity Concerns.American journal of respiratory and critical care medicine · 2024Article
Corrections and comments
- Commented on by
Authors and funding
9 authors at 6 institutions in 3 countries.
Bijan TejaInterdepartmental Division of Critical Care Medicine and.ORCID 0000-0002-4978-6353
Megan BerubeThe Pulmonary Center, Department of Medicine, Chobanian and Avedisian School of Medicine, Boston University, Boston, Massachusetts.
Tiago V PereiraClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-8574-832X
Anica C LawThe Pulmonary Center, Department of Medicine, Chobanian and Avedisian School of Medicine, Boston University, Boston, Massachusetts.ORCID 0000-0003-3616-0316
Carly SchanockMedical College of Wisconsin Libraries, Milwaukee, Wisconsin.ORCID 0000-0002-6595-541X
Brandon PangThe Pulmonary Center, Department of Medicine, Chobanian and Avedisian School of Medicine, Boston University, Boston, Massachusetts.
Hannah WunschDepartment of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-5477-8422
Allan J WalkeyDivision of Health Systems Sciences, Medical School, University of Massachusetts, Boston, Massachusetts.ORCID 0000-0003-4685-6894
Nicholas A BoschThe Pulmonary Center, Department of Medicine, Chobanian and Avedisian School of Medicine, Boston University, Boston, Massachusetts.ORCID 0000-0001-7161-5254
Boston University · USMedical College of Wisconsin · USSt. Michael's Hospital · CAUniversity of Massachusetts Boston · USUniversity of Oxford · GBUniversity of Toronto · CA
Funding
Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3MInstitutional Career DevelopmentKL2TR001411 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MORONE, NATALIA E. · 2015 to 2024
$5.9MProlonged mechanical ventilation: patterns of post-acute care and patient outcomesK23HL153482 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LAW, ANICA C · 2020 to 2024
$891kBoston University School of Medicine Department of Medicine Career Investment AwardNCATS NIH HHS KL2 TR001411NCATS NIH HHS UL1 TR001430NHLBI NIH HHS K23 HL153482NIH National Center for Advancing Translational Sciences 1KL2TR001411
Abstract
PubMed holds no abstract for this paper.
Indexed as
Anti-Inflammatory AgentsDrug Therapy, CombinationFludrocortisoneHydrocortisoneRandomized Controlled Trials as TopicShock, SepticAdultBayes TheoremFemaleHumansMaleMiddle AgedTreatment OutcomeAnti-Inflammatory AgentsFludrocortisoneHydrocortisoneadrenal cortex hormonesnetwork meta-analysissepsis
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.