Evidence map›Paper›PMID 38271475›Full record

ArticleeLife2024

Splicing factor SRSF1 is essential for homing of precursor spermatogonial stem cells in mice.

Longjie Sun, Zheng Lv, Xuexue Chen, Rong Ye, Shuang Tian, Chaofan Wang, Xiaomei Xie, Lu Yan, Xiaohong Yao, Yujing Shao and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Longjie SunState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.ORCID https://orcid.org/0000-0002-1285-3823
Zheng LvState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Xuexue ChenState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Rong YeKey Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Shuang TianState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Chaofan WangState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Xiaomei XieState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Lu YanState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Xiaohong YaoState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Yujing ShaoState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Sheng CuiCollege of Veterinary Medicine, Yangzhou University, Jiangsu, China.ORCID https://orcid.org/0000-0002-3826-3768
Juan ChenKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China, Agricultural University, Beijing, China.
Jiali LiuState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.ORCID https://orcid.org/0000-0002-6214-569X
China Agricultural University · CNChinese Academy of Sciences · CNYangzhou University · CN

Funding

National Natural Science Foundation of China 32171111Natural Science Foundation of Beijing Municipality 5222015
6 · The paper itself

Abstract

Spermatogonial stem cells (SSCs) are essential for continuous spermatogenesis and male fertility. The underlying mechanisms of alternative splicing (AS) in mouse SSCs are still largely unclear. We demonstrated that SRSF1 is essential for gene expression and splicing in mouse SSCs. Crosslinking immunoprecipitation and sequencing data revealed that spermatogonia-related genes (e.g.

Indexed as

SpermatogoniaTestisAnimalsCell Cycle ProteinsMaleMiceNeoplasm ProteinsRepressor ProteinsRNA Splicing FactorsSerine-Arginine Splicing FactorsSpermatogenesisStem CellsCell Cycle ProteinsDnd1 protein, mouseNeoplasm ProteinsRepressor ProteinsRNA Splicing FactorsSerine-Arginine Splicing FactorsSRSF10 protein, mouseSrsf1 protein, mousealternative splicingcell biologydevelopmental biologyhoming of precursor SSCsinfertilitymouseprecursor spermatogonial stem cellsSertoli cell-only syndromeSRSF1

Identifiers

PMID38271475
PMCPMC10945694
OpenAlexW4385664859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.