Evidence map›Paper›PMID 38271288›Full record

SynthesisPLoS neglected tropical diseases2024

Epidemiology of Echinococcus granulosus sensu lato in the Greater Horn of Africa: A systematic review.

Weldegebrial G Aregawi, Bruno Levecke, Hagos Ashenafi, Charles Byaruhanga, Nigatu Kebede, Erastus Mulinge, Marion Wassermann, Thomas Romig, Pierre Dorny, Veronique Dermauw

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PLoS neglected tropical diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 5 countries.

Weldegebrial G AregawiEthiopian Institute of Agricultural Research, Addis Ababa, Ethiopia.ORCID 0000-0001-7164-5031
Bruno LeveckeDepartment of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
Hagos AshenafiUnit of Animal Health and Zoonotic Diseases Research, Addis Ababa University, Aklilu Lemma Institute of Pathobiology, Addis Ababa, Ethiopia.
Charles ByaruhangaDepartment of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Pretoria, South Africa.
Nigatu KebedeUnit of Animal Health and Zoonotic Diseases Research, Addis Ababa University, Aklilu Lemma Institute of Pathobiology, Addis Ababa, Ethiopia.
Erastus MulingeKenya Medical Research Institute, Nairobi, Kenya.
Marion WassermannParasitology Unit, University of Hohenheim, Stuttgart, Germany.
Thomas RomigParasitology Unit, University of Hohenheim, Stuttgart, Germany.
Pierre DornyDepartment of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Veronique DermauwDepartment of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Addis Ababa University · ETGhent University · BEInstituut voor Tropische Geneeskunde · BEUniversity of Hohenheim · DEKenya Medical Research Institute · KEUniversity of Pretoria · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCystic echinococcosis (CE) is a neglected zoonotic disease that is caused by Echinococcus granulosus sensu lato (s.l.), the life cycle of which involves multiple hosts. We conducted a systematic review (SR) on E. granulosus s.l. in the Greater Horn of Africa (GHA), to provide a picture of its recent epidemiology across all hosts.

methodsFor this SR, conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, five electronic databases, as well experts in the region were consulted to retrieve records published between 2000 and 2022, reporting the presence of E. granulosus s.l. infections in any natural host in the GHA (Djibouti, Eritrea, Ethiopia, Kenya, Sudan, Somalia, South Sudan, Tanzania and Uganda). PRINCIPAL

findingsA total of 247 records were retained, describing the presence of E. granulosus s.l. throughout the GHA, except for Djibouti. Only few population surveys on human CE were conducted in the area, with the prevalence ranging between 0.3 and 11.3%. In animals, the reported prevalence ranged up to 61.6% in camels, 88.4% in cattle; 65.2% in goats, 9.9% in pigs, 67.8% in sheep and 94.5% in dogs. In addition, E. granulosus s.l. was also reported in wildlife. A total of five species were reported in the different hosts, namely E. granulosus sensu stricto (G1, G3, GOmo), E. canadensis (G6/7), E. ortleppi (G5), E. felidis, and E. equinus (G4).

conclusionsWe confirm that E. granulosus s.l. is prevalent throughout the GHA. Nevertheless, despite our efforts to screen grey literature, an accurate assessment of the epidemiology in GHA remains challenging, due to the lack of combined host, in-depth risk factor and behavioural studies, as well as the wide diversity in subpopulations studied and diagnostic tools used. Interdisciplinary and transboundary partnerships would be essential for the design of effective control strategies, tuned to the GHA setting.

Indexed as

EchinococcosisEchinococcus granulosusAnimalsCamelusCattleDogsEthiopiaGenotypeGoatsHumansSheepSwine

Identifiers

PMID38271288
PMCPMC10810510
OpenAlexW4391217520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.