Evidence map›Paper›PMID 38270979›Full record

ArticleACS applied materials & interfaces2024

Antibody-Conjugated Polymersomes with Encapsulated Indocyanine Green J-Aggregates and High Near-Infrared Absorption for Molecular Photoacoustic Cancer Imaging.

Mohammed R Kawelah, Sangheon Han, Ceren Atila Dincer, Jongyeong Jeon, Joel Brisola, Aasim F Hussain, Ananthakrishnan S Jeevarathinam, Richard Bouchard, Alexander E Marras, Thomas M Truskett and 2 more

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mohammed R KawelahMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0009-0003-0462-9383
Sangheon HanDepartment of Imaging Physics, MD Anderson Cancer Center, Houston, Texas 77030, United States.ORCID 0000-0003-0626-3162
Ceren Atila DincerMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.
Jongyeong JeonMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.
Joel BrisolaMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.
Aasim F HussainDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0003-2083-8903
Ananthakrishnan S JeevarathinamDepartment of Imaging Physics, MD Anderson Cancer Center, Houston, Texas 77030, United States.ORCID 0000-0003-1294-9451
Richard BouchardDepartment of Imaging Physics, MD Anderson Cancer Center, Houston, Texas 77030, United States.
Alexander E MarrasWalker Department of Mechanical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0001-8972-9532
Thomas M TruskettMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0002-6607-6468
Konstantin V SokolovDepartment of Imaging Physics, MD Anderson Cancer Center, Houston, Texas 77030, United States.ORCID 0000-0002-0198-2005
Keith P JohnstonMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0002-0915-1337

Funding

Molecular Photoacoustic Imaging for Diagnostics and Therapy MonitoringR01EB028762 · NIBIB · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BOUCHARD, RICHARD R. · 2020 to 2024
$3.1M
NIBIB NIH HHS R01 EB028762
6 · The paper itself

Abstract

Imaging plays a critical role in all stages of cancer care from early detection to diagnosis, prognosis, and therapy monitoring. Recently, photoacoustic imaging (PAI) has started to emerge into the clinical realm due to its high sensitivity and ability to penetrate tissues up to several centimeters deep. Herein, we encapsulated indocyanine green J (ICGJ) aggregate, one of the only FDA-approved organic exogenous contrast agents that absorbs in the near-infrared range, at high loadings up to ∼40% w/w within biodegradable polymersomes (ICGJ-Ps) composed of poly(lactide-

Indexed as

ImmunoconjugatesPhotoacoustic TechniquesContrast MediaErbB ReceptorsIndocyanine GreenMolecular ImagingSpectrum AnalysisContrast MediaErbB ReceptorsImmunoconjugatesIndocyanine Greenbreast cancerindocyanine greenJ-aggregatesphotoacoustic imagingpolymersomes

Identifiers

PMID38270979
PMCPMC11246536

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.