Evidence map›Paper›PMID 38270898›Full record

SynthesisAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Occupational and domestic exposure associations with cerebral small vessel disease and vascular dementia: A systematic review and meta-analysis.

Una Clancy, Yajun Cheng, Amrita Brara, Fergus N Doubal, Joanna M Wardlaw

Open access · hybridAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 4 pooled it
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 4 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Una ClancyCentre for Clinical Brain Sciences and the UK Dementia Research Institute, Chancellor's Building, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-8062-7537
Yajun ChengCenter of Cerebrovascular Diseases, Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0002-5227-9811
Amrita BraraCentre for Clinical Brain Sciences and the UK Dementia Research Institute, Chancellor's Building, University of Edinburgh, Edinburgh, UK.
Fergus N DoubalCentre for Clinical Brain Sciences and the UK Dementia Research Institute, Chancellor's Building, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-2769-3148
Joanna M WardlawCentre for Clinical Brain Sciences and the UK Dementia Research Institute, Chancellor's Building, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-9812-6642
UK Dementia Research Institute · GBSichuan University · CN

Funding

China Scholarship CouncilFondation Leducq Transatlantic Network of Excellence for the Study of Perivascular Spaces in Small Vessel Disease ref no. 16 CVD 05NHS Research ScotlandRow Fogo Charitable Trust Centre for Research into Aging and the BrainScottish Clinical Research Excellence Development Scheme Clinical Lectureship at the University of EdinburghStroke Association Garfield Weston Foundation TSALECT 2015/04UK Dementia Research Institute, funded by the UK Medical Research Council, Alzheimer's Society and Alzheimer's Research UK
6 · The paper itself

Abstract

introductionThe prevalence of cerebral smallvessel disease (SVD) and vascular dementia according to workplace or domestic exposure to hazardous substances is unclear.

methodsWe included studies assessing occupational and domestic hazards/at-risk occupations and SVD features. We pooled prevalence estimates using random-effects models where possible, or presented a narrative synthesis.

resultsWe included 85 studies (n = 47,743, mean age = 44·5 years). 52/85 reported poolable estimates. SVD prevalence in populations exposed to carbon monoxide was 81%(95% CI = 60-93%; n = 1373; results unchanged in meta-regression), carbon disulfide73% (95% CI = 54-87%; n = 131), 1,2-dichloroethane 88% (95% CI = 4-100%, n = 40), toluene 82% (95% CI = 3-100%, n = 64), high altitude 49% (95% CI = 38-60%; n = 164),and diving 24% (95% CI = 5-67%, n = 172). We narratively reviewed vascular dementia studies and contact sport, lead, military, pesticide, and solvent exposures as estimates were too few/varied to pool. DISCUSSION: SVD and vascular dementia may be associated with occupational/domestic exposure to hazardous substances. CRD42021297800.

Indexed as

Cerebral Small Vessel DiseasesDementia, VascularOccupational ExposureEnvironmental ExposureHazardous SubstancesHumansPrevalenceHazardous Substancescerebral small vessel diseasedementiaoccupationspublic healthstrokewhite matter hyperintensitiesworkplace

Identifiers

PMID38270898
PMCPMC11032565
OpenAlexW4391218801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.