Evidence map›Paper›PMID 38270728›Full record

Trial reportNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

Effect of neuronavigated repetitive Transcranial Magnetic Stimulation on pain, cognition and cortical excitability in fibromyalgia syndrome.

Vikas Kumar Tiwari, Aasheesh Kumar, Srishti Nanda, Shefali Chaudhary, Ratna Sharma, Uma Kumar, Senthil S Kumaran, Renu Bhatia

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. [Fibromyalgia syndrome].Innere Medizin (Heidelberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vikas Kumar TiwariPain Research and TMS Laboratory, Department of Physiology, All India Institute of Medical Sciences, New Delhi, India, 110029.
Aasheesh KumarPain Research and TMS Laboratory, Department of Physiology, All India Institute of Medical Sciences, New Delhi, India, 110029.ORCID http://orcid.org/0000-0003-2334-5872
Srishti NandaPain Research and TMS Laboratory, Department of Physiology, All India Institute of Medical Sciences, New Delhi, India, 110029.
Shefali ChaudharyDepartment of Nuclear Magnetic Resonance and MRI Facility, New Delhi, India.
Ratna SharmaStress and Cognition Electroimaging Laboratory, Department of Physiology, New Delhi, India.
Uma KumarDepartment of Rheumatology, All India Institute of Medical Sciences (AIIMS), New Delhi, India, 110029.
Senthil S KumaranDepartment of Nuclear Magnetic Resonance and MRI Facility, New Delhi, India.
Renu BhatiaPain Research and TMS Laboratory, Department of Physiology, All India Institute of Medical Sciences, New Delhi, India, 110029. renuaiims28@gmail.com.ORCID http://orcid.org/0000-0002-3022-5281

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFibromyalgia syndrome is a widespread chronic pain condition identified by body-wide pain, fatigue, cognitive fogginess, and sleep issues. In the past decade, repetitive transcranial magnetic stimulation has emerged as a potential management tool.. In the present study, we enquired whether repetitive transcranial magnetic stimulation could modify pain, corticomotor excitability, cognition, and sleep.

methodsStudy is a randomized, sham-controlled, double-blind, clinical trial; wherein after randomizing thirty-four fibromyalgia patients into active or sham therapy (n = 17 each), each participant received repetitive transcranial magnetic stimulation therapy. In active therapy was given at 1 Hz for 20 sessions were delivered on dorsolateral prefrontal cortex (1200 pulses, 150 pulses per train for 8 trains); while in sham therapy coil was placed at right angle to the scalp with same frequency. Functional magnetic resonance imaging was used to identify the therapeutic site. Pain intensity, corticomotor excitability, cognition, and sleep were examined before and after therapy.

resultsBaseline demographic and clinical parameters for both active and sham groups were comparable. In comparison to sham, active repetitive transcranial magnetic stimulation showed significant difference in pain intensity (P < 0.001, effect size = 0.29, large effect) after intervention. Other parameters of pain perception, cognition, and sleep quality also showed a significant improvement after the therapy in active therapy group only, as compared to sham.

conclusionsFindings suggest that repetitive transcranial magnetic stimulation intervention is effective in managing pain alongside cognition and sleep disturbances in patients of fibromyalgia. It may prove to be an important tool in relieving fibromyalgia-associated morbidity.

Indexed as

Cortical ExcitabilityFibromyalgiaTranscranial Magnetic StimulationAdultCognitionDouble-Blind MethodFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPain MeasurementTreatment OutcomeChronic PainCognition and SleepDorsolateral Prefrontal CortexFibromyalgia SyndromeRandomized Controlled TrialRepetitive Transcranial Magnetic Stimulation

Identifiers

PMID38270728

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.