Evidence map›Paper›PMID 38269906›Full record

ArticleStudies in health technology and informatics2024

Transfer Learning for Mortality Prediction in Non-Small Cell Lung Cancer with Low-Resolution Histopathology Slide Snapshots.

Matthew Clark, Christopher Meyer, Jaime Ramos-Cejudo, Danne C Elbers, Karen Pierce-Murray, Rafael Fricks, Gil Alterovitz, Luigi Rao, Mary T Brophy, Nhan V Do and 2 more

Abstract read
In one paragraph

Article in Studies in health technology and informatics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Matthew ClarkCenter for Translational Data Science, University of Chicago, Chicago, IL.
Christopher MeyerCenter for Translational Data Science, University of Chicago, Chicago, IL.
Jaime Ramos-CejudoVA Boston Healthcare System, Boston, MA.
Danne C ElbersVA Boston Healthcare System, Boston, MA.
Karen Pierce-MurrayVA Boston Healthcare System, Boston, MA.
Rafael FricksNational Artificial Intelligence Institute, Dept. of Veterans Affairs, Washington, DC.
Gil AlterovitzHarvard Medical School, Boston, MA.
Luigi RaoDept. of Pathology, Walter Reed National Military Medical Center, Bethesda, MD.
Mary T BrophyVA Boston Healthcare System, Boston, MA.
Nhan V DoVA Boston Healthcare System, Boston, MA.
Robert L GrossmanCenter for Translational Data Science, University of Chicago, Chicago, IL.
Nathanael R FillmoreVA Boston Healthcare System, Boston, MA.

Funding

Intramural VA VA999999
6 · The paper itself

Abstract

High-resolution whole slide image scans of histopathology slides have been widely used in recent years for prediction in cancer. However, in some cases, clinical informatics practitioners may only have access to low-resolution snapshots of histopathology slides, not high-resolution scans. We evaluated strategies for training neural network prognostic models in non-small cell lung cancer (NSCLC) based on low-resolution snapshots, using data from the Veterans Affairs Precision Oncology Data Repository. We compared strategies without transfer learning, with transfer learning from general domain images, and with transfer learning from publicly available high-resolution histopathology scans. We found transfer learning from high-resolution scans achieved significantly better performance than other strategies. Our contribution provides a foundation for future development of prognostic models in NSCLC that incorporate data from low-resolution pathology slide snapshots alongside known clinical predictors.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsMedical InformaticsHumansMachine LearningPrecision Medicinedeep learningmedical imagespathologyprognosistransfer learning

Identifiers

PMID38269906
PMCPMC11128309

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.