Evidence map›Paper›PMID 38269887›Full record

ArticleStudies in health technology and informatics2024

Extracting Drug-Protein Relation from Literature Using Ensembles of Biomedical Transformers.

Avisha Das, Zhao Li, Qiang Wei, Jianfu Li, Liang-Chin Huang, Yan Hu, Rongbin Li, Wenjin Jim Zheng, Hua Xu

Open access · hybridAbstract read
In one paragraph

Article in Studies in health technology and informatics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Avisha DasSchool of Biomedical Informatics, University of Texas Health Science Center at Houston; Yale University; Melax Technologies, Houston.
Zhao LiSchool of Biomedical Informatics, University of Texas Health Science Center at Houston; Yale University; Melax Technologies, Houston.
Qiang WeiSchool of Biomedical Informatics, University of Texas Health Science Center at Houston; Yale University; Melax Technologies, Houston.
Jianfu LiSchool of Biomedical Informatics, University of Texas Health Science Center at Houston; Yale University; Melax Technologies, Houston.
Liang-Chin HuangSchool of Biomedical Informatics, University of Texas Health Science Center at Houston; Yale University; Melax Technologies, Houston.
Yan HuSchool of Biomedical Informatics, University of Texas Health Science Center at Houston; Yale University; Melax Technologies, Houston.
Rongbin LiSchool of Biomedical Informatics, University of Texas Health Science Center at Houston; Yale University; Melax Technologies, Houston.
Wenjin Jim ZhengSchool of Biomedical Informatics, University of Texas Health Science Center at Houston; Yale University; Melax Technologies, Houston.
Hua XuSchool of Biomedical Informatics, University of Texas Health Science Center at Houston; Yale University; Melax Technologies, Houston.

Funding

Convalescent Plasma to Limit Coronavirus Associated ComplicationsUL1TR003167 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARP, DANIEL D, MCPHERSON, DAVID D · 2019 to 2023
$45.3M
TRAINING PROGRAM IN COMPUTATIONAL BIOLOGY AND MEDICINET15LM007093 · NLM · RICE UNIVERSITY · PI Lydia E. Kavraki · 1992 to 2026
$20.8M
Finding Combinatorial Drug Repositioning Therapy For Alzheimer'S Disease And Related DementiasR01AG066749 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI JIANG, XIAOQIAN, ZHENG, WENJIN JIM · 2020 to 2024
$4.4M
Advancing Drug Repositioning for Alzheimer’s Disease using Real-world DataR56AG069880 · NIA · UNIVERSITY OF FLORIDA · PI BIAN, JIANG, CHEN, YONG · 2021 to 2022
$1.6M
NCATS NIH HHS UL1 TR003167NIA NIH HHS R01 AG066749NIA NIH HHS R56 AG069880NLM NIH HHS T15 LM007093
6 · The paper itself

Abstract

Automatic extraction of relations between drugs/chemicals and proteins from ever-growing biomedical literature is required to build up-to-date knowledge bases in biomedicine. To promote the development of automated methods, BioCreative-VII organized a shared task - the DrugProt track, to recognize drug-protein entity relations from PubMed abstracts. We participated in the shared task and leveraged deep learning-based transformer models pre-trained on biomedical data to build ensemble approaches to automatically extract drug-protein relation from biomedical literature. On the main corpora of 10,750 abstracts, our best system obtained an F1-score of 77.60% (ranked 4th among 30 participating teams), and on the large-scale corpus of 2.4M documents, our system achieved micro-averaged F1-score of 77.32% (ranked 2nd among 9 system submissions). This demonstrates the effectiveness of domain-specific transformer models and ensemble approaches for automatic relation extraction from biomedical literature.

Indexed as

Electric Power SuppliesKnowledge BasesPubMedBERTDeep LearningDrug-protein relation extractionEnsemble LearningPubmed abstracts

Identifiers

PMID38269887
PMCPMC13034061
OpenAlexW4391229233

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.