Evidence map›Paper›PMID 38269489›Full record

ArticlemAbs

Variable domain mutational analysis to probe the molecular mechanisms of high viscosity of an IgG

Jing Dai, Saeed Izadi, Jonathan Zarzar, Patrick Wu, Angela Oh, Paul J Carter

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mAbs. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
9.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  3. Fab-Fc and Fab-Fab interactions of variable strength and valency contribute to the high concentration viscosity of IgGProceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jing DaiDepartment of Antibody Engineering, Genentech, Inc, South San Francisco, CA, USA.ORCID 0000-0002-9819-0206
Saeed IzadiDepartment of Pharmaceutical Development, Genentech, Inc, South San Francisco, CA, USA.ORCID 0000-0003-4206-8559
Jonathan ZarzarDepartment of Pharmaceutical Development, Genentech, Inc, South San Francisco, CA, USA.
Patrick WuDepartment of Bioanalytical Sciences, Genentech, Inc, South San Francisco, CA, USA.ORCID 0000-0002-1437-6688
Angela OhDepartment of Structural Biology, Genentech, Inc, South San Francisco, CA, USA.
Paul J CarterDepartment of Antibody Engineering, Genentech, Inc, South San Francisco, CA, USA.ORCID 0000-0001-7854-062X
Bioanalytical Systems (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subcutaneous injection is the preferred route of administration for many antibody therapeutics for reasons that include its speed and convenience. However, the small volume limit (typically

Indexed as

Antibodies, Monoclonal, HumanizedComplementarity Determining RegionsImmunoglobulin GMolecular Dynamics SimulationViscosityAntibodies, Monoclonal, HumanizedComplementarity Determining RegionsImmunoglobulin GAntibodyintermolecular interactionsmulti-parameter optimizationreversible self-associationrheologysubcutaneous deliveryviscosity

Identifiers

PMID38269489
PMCPMC10813588
OpenAlexW4391229221

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.