Evidence map›Paper›PMID 38268931›Full record

ArticleNeurobiology of stress2024

Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline.

Laurel R Seemiller, Julio Flores-Cuadra, Keith R Griffith, Grace C Smith, Nicole A Crowley

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of stress, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Interconnections of screen time with neuroinflammation.Molecular and cellular biochemistry · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Life (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Laurel R SeemillerDepartment of Biology, The Pennsylvania State University, University Park, PA, 16802, USA.
Julio Flores-CuadraDepartment of Biology, The Pennsylvania State University, University Park, PA, 16802, USA.
Keith R GriffithDepartment of Biology, The Pennsylvania State University, University Park, PA, 16802, USA.
Grace C SmithDepartment of Biology, The Pennsylvania State University, University Park, PA, 16802, USA.
Nicole A CrowleyDepartment of Biology, The Pennsylvania State University, University Park, PA, 16802, USA.
Pennsylvania State University · US

Funding

Social Anxiety, Stress and Ethanol Sensitivity in Adolescence and AdulthoodP50AA017823 · NIAAA · UPSTATE MEDICAL UNIVERSITY · PI Marvin Rafael Diaz · 2009 to 2026
$30.5M
Research Training in Physiological Adaptations to StressT32GM108563 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CANTORNA, MARGHERITA T, KORZICK, DONNA HOPE · 2014 to 2023
$2.2M
Prelimbic somatostatin peptide signaling in binge ethanol consumptionR01AA029403 · NIAAA · PENNSYLVANIA STATE UNIVERSITY, THE · PI Nicole Ashley Crowley · 2022 to 2026
$1.9M
NIAAA NIH HHS P50 AA017823NIAAA NIH HHS R01 AA029403NIGMS NIH HHS T32 GM108563
6 · The paper itself

Abstract

Alzheimer's Disease and related dementias (ADRD) are an increasing threat to global health initiatives. Efforts to prevent the development of ADRD require understanding behaviors that increase and decrease risk of neurodegeneration and cognitive decline, in addition to uncovering the underlying biological mechanisms behind these effects. Stress exposure and alcohol consumption have both been associated with increased risk for ADRD in human populations. However, our ability to understand causal mechanisms of ADRD requires substantial preclinical research. In this review, we summarize existing human and animal research investigating the connections between lifetime stress and alcohol exposures and ADRD.

Indexed as

AdolescenceAlcoholAlzheimer's DiseaseCognitive declineLifespanNeurodegenerationStress

Identifiers

PMID38268931
PMCPMC10806346
OpenAlexW4390590912

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.