Evidence map›Paper›PMID 38268923›Full record

ArticleFrontiers in immunology2023

Antigen-presenting B cells promote TCF-1

David Hou, Hanxiao Wan, Joshua L Katz, Si Wang, Brandyn A Castro, Gustavo I Vazquez-Cervantes, Victor A Arrieta, Silpol Dhiantravan, Hinda Najem, Aida Rashidi and 11 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 9 citations in OpenAlex.

  1. B cells in cancer: functions, mechanisms and therapeutic advances.Signal transduction and targeted therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 1 country.

David Hou *Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Hanxiao Wan *Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Joshua L KatzDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Si WangDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Brandyn A CastroDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Gustavo I Vazquez-CervantesDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Victor A ArrietaDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Silpol DhiantravanDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Hinda NajemDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Aida RashidiDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Tzu-Yi ChiaDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Tarlan ArjmandiDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Jimena ColladoDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Leah BillinghamDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Aurora Lopez-RosasDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Yu HanDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Adam M SonabendDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Amy B HeimbergerDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Peng ZhangDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Jason MiskaDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Catalina Lee-ChangDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Neurological Surgery · USNorthwestern University · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
STINGing GBM: A First-in- Man Clinical Trial in Surgical Resectable Recurrent GBMP50CA221747 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Atique U. Ahmed · 2018 to 2026
$21.4M
Development of B-cell-based vaccine for GlioblastomaR37CA258426 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Catalina Lee Chang · 2021 to 2026
$2.2M
Arginine Metabolism Regulates Myeloid Immune Suppression in GlioblastomaR01NS115955 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LESNIAK, MACIEJ S, MISKA, JASON · 2020 to 2024
$1.9M
The hypoxic niche in glioblastoma is maintained by myeloid produced creatineR01CA279686 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Jason Miska · 2023 to 2026
$1.5M
NCI NIH HHS P30 CA060553NCI NIH HHS P50 CA221747NCI NIH HHS R01 CA279686NCI NIH HHS R37 CA258426NINDS NIH HHS R01 NS115955
6 · The paper itself

Abstract

Understanding the spatial relationship and functional interaction of immune cells in glioblastoma (GBM) is critical for developing new therapeutics that overcome the highly immunosuppressive tumor microenvironment. Our study showed that B and T cells form clusters within the GBM microenvironment within a 15-μm radius, suggesting that B and T cells could form immune synapses within the GBM. However, GBM-infiltrating B cells suppress the activation of CD8

Indexed as

GlioblastomaAntigen-Presenting CellsCD8-Positive T-LymphocytesCell ProliferationGranzymesHumansProgrammed Cell Death 1 ReceptorTumor MicroenvironmentGranzymesProgrammed Cell Death 1 Receptoranti-tumor responseB cellsGBMimmunological synapsestem-like memory CD8+ T cell

Identifiers

PMID38268923
PMCPMC10806106
OpenAlexW4390699504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.