Evidence map›Paper›PMID 38268544›Full record

ArticleRSC advances2024

Cross aldol OPAL bioconjugation outcompetes intramolecular hemiaminal cyclisation of proline adjacent N-terminal α-oxo aldehydes at acidic pH.

Afzaal Tufail, Saeed Akkad, Natasha E Hatton, Nicholas D J Yates, Richard J Spears, Tessa Keenan, Alison Parkin, Nathalie Signoret, Martin A Fascione

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Afzaal TufailDepartment of Chemistry, University of York Heslington York YO10 5DD UK martin.fascione@york.ac.uk.
Saeed AkkadDepartment of Chemistry, University of York Heslington York YO10 5DD UK martin.fascione@york.ac.uk.ORCID https://orcid.org/0000-0002-7271-0496
Natasha E HattonDepartment of Chemistry, University of York Heslington York YO10 5DD UK martin.fascione@york.ac.uk.
Nicholas D J YatesDepartment of Chemistry, University of York Heslington York YO10 5DD UK martin.fascione@york.ac.uk.
Richard J SpearsDepartment of Chemistry, University of York Heslington York YO10 5DD UK martin.fascione@york.ac.uk.ORCID https://orcid.org/0000-0001-9846-8637
Tessa KeenanDepartment of Chemistry, University of York Heslington York YO10 5DD UK martin.fascione@york.ac.uk.ORCID https://orcid.org/0000-0003-2466-6918
Alison ParkinDepartment of Chemistry, University of York Heslington York YO10 5DD UK martin.fascione@york.ac.uk.ORCID https://orcid.org/0000-0003-4715-7200
Nathalie SignoretHull York Medical School, University of York YO10 5DD UK nathalie.signoret@york.ac.uk.
Martin A FascioneDepartment of Chemistry, University of York Heslington York YO10 5DD UK martin.fascione@york.ac.uk.ORCID https://orcid.org/0000-0002-0066-4419
University of York · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel methods to construct small molecule-protein bioconjugates are integral to the development of new biomedicines for a variety of diseases. C-C linked bioconjugates are increasingly desirable in this application due to their

Identifiers

PMID38268544
PMCPMC10806391
OpenAlexW4391177018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.