Evidence map›Paper›PMID 38268306›Full record

ArticleEndocrinology, diabetes & metabolism2024

Copeptin and the syndrome of inappropriate antidiuresis (SIAD) after pituitary transsphenoidal surgery.

Agathoklis Efthymiadis, Riccardo Pofi, Hussam Rostom, Tim James, Brian Shine, Nish Guha, Simon Cudlip, Mirjam Christ-Crain, Aparna Pal

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Article in Endocrinology, diabetes & metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Agathoklis EfthymiadisOxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.ORCID 0000-0002-5296-6638
Riccardo PofiOxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Hussam RostomDepartment of Clinical Biochemistry, John Radcliffe Hospital, Oxford, UK.
Tim JamesDepartment of Clinical Biochemistry, John Radcliffe Hospital, Oxford, UK.
Brian ShineDepartment of Clinical Biochemistry, John Radcliffe Hospital, Oxford, UK.
Nish GuhaDepartment of Clinical Biochemistry, John Radcliffe Hospital, Oxford, UK.
Simon CudlipDepartment of Neurosurgery, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Mirjam Christ-CrainDivision of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland.
Aparna PalOxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study evaluates the predictive value of copeptin for syndrome of inappropriate antidiuresis (SIAD) postpituitary transsphenoidal surgery (TSS).

designData from 133 consecutive patients undergoing TSS (November 2017-October 2022) at Oxford University Hospitals NHS trust are presented in this retrospective study.

methodsLogistic regression (LR) and receiver operating characteristic (ROC) curves were performed to evaluate the diagnostic utility of copeptin. The Mann-Whitney U test was used to compare copeptin levels between the SIAD and no SIAD groups.

resultsFourteen patients (10.8%) developed SIAD. Copeptin was available in 121, 53 and 87 patients for Days 1, 241 and 8 post-TSS, respectively. LR for Day 1 copeptin to predict SIAD gave an odds ratio (OR) of 1.0 (95%CI 42 0.84-1.20, p = .99), area under-ROC curve (AUC) was 0.49; Day 2 copeptin OR was 0.65 (95%CI 0.39-1.19, 43 p = .77), AUC was 0.57 LR for Day 1 sodium to predict SIAD gave an odds ratio (OR) of 1.0 (95%CI 0.85-1.21, p = .99), AUC was 0.50.

conclusionsIn conclusion, our data provide no evidence for copeptin as a predictive marker for post-TSS SIAD.

Indexed as

GlycopeptidesHumansRetrospective StudiesROC CurvecopeptinsGlycopeptidescopeptinhyponatraemiapituitary transsphenoidal surgerysyndrome of inappropriate antidiuresis

Identifiers

PMID38268306
PMCPMC10794156

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.