Evidence map›Paper›PMID 38267943›Full record

ArticleBMC pregnancy and childbirth2024

Systemic inflammation, enteropathogenic E. Coli, and micronutrient insufficiencies in the first trimester as possible predictors of preterm birth in rural Bangladesh: a prospective study.

Meghan K Gerety, Debora K Kim, Rebecca M Carpenter, Jennie Z Ma, Christian Chisholm, Mami Taniuchi, Md Ohedul Islam, Suporn Pholwat, James A Platts-Mills, Md Shahjahan Siraj and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Meghan K Gerety *Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Meghan.Gerety@Pennmedicine.upenn.edu.
Debora K Kim *Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.
Rebecca M CarpenterDepartment of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.
Jennie Z MaDepartment of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA.
Christian ChisholmDepartment of Obstetrics and Gynecology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Mami TaniuchiDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, VA, USA.
Md Ohedul IslamThe International Centre for Diarrhoeal Disease and Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Suporn PholwatDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, VA, USA.
James A Platts-MillsDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, VA, USA.
Md Shahjahan SirajThe International Centre for Diarrhoeal Disease and Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Sk Masum BillahThe International Centre for Diarrhoeal Disease and Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Rashidul HaqueThe International Centre for Diarrhoeal Disease and Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
William A PetriDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, VA, USA.
University of Virginia · USInternational Centre for Diarrhoeal Disease Research · BDThe University of Texas Medical Branch at Galveston · USUniversity of Pennsylvania · US

Funding

University of Virginia - icddr,b Research Unit for Women's and Children's Health ResearchUG1HD096730 · NICHD · UNIVERSITY OF VIRGINIA · PI Christian A Chisholm · 2018 to 2026
$5.3M
NICHD NIH HHS UG1 HD096730
6 · The paper itself

Abstract

backgroundAn incomplete understanding of preterm birth is especially concerning for low-middle income countries, where preterm birth has poorer prognoses. While systemic proinflammatory processes are a reportedly normal component of gestation, excessive inflammation has been demonstrated as a risk factor for preterm birth. There is minimal research on the impact of excessive maternal inflammation in the first trimester on the risk of preterm birth in low-middle income countries specifically.

methodsPregnant women were enrolled at the rural Bangladesh site of the National Institute of Child Health Global Network Maternal Newborn Health Registry. Serum samples were collected to measure concentrations of the inflammatory markers C-reactive protein (CRP) and Alpha-1-acid glycoprotein (AGP), and stool samples were collected and analyzed for enteropathogens. We examined associations of maternal markers in the first-trimester with preterm birth using logistic regression models. CRP and AGP were primarily modeled with a composite inflammation predictor.

resultsOut of 376 singleton births analyzed, 12.5% were preterm. First trimester inflammation was observed in 58.8% of all births, and was significantly associated with increased odds of preterm birth (adjusted odds ratio [aOR] = 2.23; 95% confidence interval [CI]: 1.03, 5.16), independent of anemia. Maternal vitamin B12 insufficiency (aOR = 3.33; 95% CI: 1.29, 8.21) and maternal anemia (aOR = 2.56; 95% CI: 1.26, 5.17) were also associated with higher odds of preterm birth. Atypical enteropathogenic E. coli detection showed a significant association with elevated AGP levels and was significantly associated with preterm birth (odds ratio [OR] = 2.36; 95% CI: 1.21, 4.57), but not associated with CRP.

conclusionsInflammation, anemia, and vitamin B12 insufficiency in the first trimester were significantly associated with preterm birth in our cohort from rural Bangladesh. Inflammation and anemia were independent predictors of premature birth in this low-middle income setting where inflammation during gestation was widespread. Further research is needed to identify if infections such as enteropathogenic E. coli are a cause of inflammation in the first trimester, and if intervention for infection would decrease preterm birth.

Indexed as

AnemiaEnteropathogenic Escherichia coliPremature BirthTrace ElementsBangladeshChildC-Reactive ProteinFemaleHumansInfant, NewbornInflammationMicronutrientsPregnancyPregnancy Trimester, FirstProspective StudiesVitamin B 12C-Reactive ProteinMicronutrientsTrace ElementsVitamin B 12anemiaEarly pregnancyEnteric pathogensInflammationPremature birth

Identifiers

PMID38267943
PMCPMC10807221
OpenAlexW4391175020

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.