Evidence map›Paper›PMID 38267841›Full record

ArticleBMC infectious diseases2024

Mitochondrial disturbance related to increased caspase-1 of CD4

Fengting Yu, Chengjie Ma, Xia Jin, Hongxin Zhao, Jiang Xiao, Li Li, Shujing Song, Xiaohui Xie, Siyuan Yang, Yunxia Tang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
  2. DisseminatedOpen forum infectious diseases · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Fengting YuMedical School, University of Chinese Academy of Sciences, Beijing, 101400, China.
Chengjie MaBeijing Ditan Hospital, Capital Medical University, Beijing, China.
Xia JinHuman Viral Diseases and Vaccine Translation Research Unit, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Hongxin ZhaoBeijing Ditan Hospital, Capital Medical University, Beijing, China.
Jiang XiaoBeijing Ditan Hospital, Capital Medical University, Beijing, China.
Li LiBeijing Ditan Hospital, Capital Medical University, Beijing, China.
Shujing SongBeijing Ditan Hospital, Capital Medical University, Beijing, China.
Xiaohui XieDepartment of Infectious Diseases, Peking University Ditan Teaching, Hospital, Beijing, China.
Siyuan YangBeijing Ditan Hospital, Capital Medical University, Beijing, China.
Yunxia TangBeijing Ditan Hospital, Capital Medical University, Beijing, China.
Linghang WangBeijing Ditan Hospital, Capital Medical University, Beijing, China. ditanwanglinghang@163.com.
Fujie ZhangMedical School, University of Chinese Academy of Sciences, Beijing, 101400, China. treatment@chinaaids.cn.
Capital Medical University · CNInstitut Pasteur of Shanghai · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn HIV-1 infection, more than 95% of CD4

methodsBlood samples were obtained from 31 untreated HIV-infected patients (UNT), 29 antiretroviral therapy treated HIV-infected patients (ART), and 21 healthy control donors (HD). Plasma levels of IL-18 and IL-1β, caspase-1 expression, mitochondrial mass (MM) and mitochondrial fusion/fisson genes of CD4

resultsA significantly higher IL-18 level in plasma and MM level of CD4

conclusionAn increase in MM was associated with heightened sensitivity of CD4

Indexed as

HIV-1HIV InfectionsCaspase 1HumansInterleukin-18T-LymphocytesCaspase 1Interleukin-18CD4+T pyroptosisHIV/AIDSMFN1Mitochondrial mass

Identifiers

PMID38267841
PMCPMC10809604
OpenAlexW4391168145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.