ArticleCommunications biology2024
Modular subgraphs in large-scale connectomes underpin spontaneous co-fluctuation events in mouse and human brains.
Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The dual interpretation of edge time series: Time-varying connectivity versus statistical interaction.iScience · 2026Article
- Global topology of brain-wide co-fluctuations links task states, personality, and behavioral symptom dimensions.bioRxiv : the preprint server for biology · 2026Article
- Long-range axon branching: contributions to brain network plasticity and repair.Nature reviews. Neuroscience · 2026Review
- Variation in high-amplitude events across the human lifespan.Network neuroscience (Cambridge, Mass.) · 2026Article
- Cognitive and neural mechanisms of mental imagery supporting creative cognition.Communications biology · 2025Article
- Structural and genetic determinants of zebrafish functional brain networks.Science advances · 2025Article
- Structural differences between human and mouse neurons and their implementation in generative AIs.Scientific reports · 2025Article
- Multiscale brain modeling: bridging microscopic and macroscopic brain dynamics for clinical and technological applications.Frontiers in cellular neuroscience · 2025Review
- Evolutionarily conserved fMRI network dynamics in the mouse, macaque, and human brain.Nature communications · 2024Article
- Spatiotemporal relationships between neuronal, metabolic, and hemodynamic signals in the awake and anesthetized mouse brain.Cell reports · 2024Article
- Distinct Time-Resolved Brain-Wide Coactivations in Oxygenated and Deoxygenated Hemoglobin.IEEE transactions on bio-medical engineering · 2024Article
- Living on the edge: network neuroscience beyond nodes.Trends in cognitive sciences · 2023Review
- Synchronous high-amplitude co-fluctuations of functional brain networks during movie-watching.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Mapping high-amplitude fMRI edge time series events across space and time.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Previous studies have adopted an edge-centric framework to study fine-scale network dynamics in human fMRI. To date, however, no studies have applied this framework to data collected from model organisms. Here, we analyze structural and functional imaging data from lightly anesthetized mice through an edge-centric lens. We find evidence of "bursty" dynamics and events - brief periods of high-amplitude network connectivity. Further, we show that on a per-frame basis events best explain static FC and can be divided into a series of hierarchically-related clusters. The co-fluctuation patterns associated with each cluster centroid link distinct anatomical areas and largely adhere to the boundaries of algorithmically detected functional brain systems. We then investigate the anatomical connectivity undergirding high-amplitude co-fluctuation patterns. We find that events induce modular bipartitions of the anatomical network of inter-areal axonal projections. Finally, we replicate these same findings in a human imaging dataset. In summary, this report recapitulates in a model organism many of the same phenomena observed in previously edge-centric analyses of human imaging data. However, unlike human subjects, the murine nervous system is amenable to invasive experimental perturbations. Thus, this study sets the stage for future investigation into the causal origins of fine-scale brain dynamics and high-amplitude co-fluctuations. Moreover, the cross-species consistency of the reported findings enhances the likelihood of future translation.
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