Evidence map›Paper›PMID 38267533›Full record

Trial reportEuropean journal of clinical nutrition2024

Effects on cardiovascular risk factors of a low- vs high-glycemic index Mediterranean diet in high cardiometabolic risk individuals: the MEDGI-Carb study.

Giuseppina Costabile, Robert E Bergia, Marilena Vitale, Therese Hjorth, Wayne Campbell, Rikard Landberg, Gabriele Riccardi, Rosalba Giacco

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03410719 (Effectiveness of Pasta and Other Starchy Foods With a Low Glycemic Response to Promote Cardio-metabolic and Emotional Well-being.), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03410719 nacompletednot on this map

Effectiveness of Pasta and Other Starchy Foods With a Low Glycemic Response to Promote Cardio-metabolic and Emotional Well-being.

TypeinterventionalSponsorPurdue UniversityRan2018 to 2020Enrolled166ConditionsInsulin SensitivityArmsHi GI
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giuseppina CostabileDepartment of Clinical Medicine and Surgery, Federico II University, Naples, Italy. giuseppina.costabile@unina.it.ORCID http://orcid.org/0000-0001-5761-8002
Robert E BergiaDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.
Marilena VitaleDepartment of Clinical Medicine and Surgery, Federico II University, Naples, Italy.ORCID http://orcid.org/0000-0001-9951-4674
Therese HjorthDepartment of Biology and Biological Engineering, Food Science and Nutrition, Chalmers University of Technology, Gothenburg, Sweden.ORCID http://orcid.org/0000-0001-6868-833X
Wayne CampbellDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0002-7847-7242
Rikard LandbergDepartment of Biology and Biological Engineering, Food Science and Nutrition, Chalmers University of Technology, Gothenburg, Sweden.
Gabriele RiccardiDepartment of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
Rosalba GiaccoInstitute of Food Sciences, National Research Council, Avellino, Italy.ORCID http://orcid.org/0000-0002-4006-9761

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of dietary Glycemic Index (GI), independently of fiber intake, in modulating cardiovascular disease (CVD) risk among non-diabetic individuals has not been fully elucidated.

objectiveTo evaluate the effects of a low- versus a high-GI diet, based on a Mediterranean dietary pattern, on cardiometabolic risk factors in individuals at high CVD risk, participating in the MEDGI-Carb intervention study. SUBJECTS AND

methods160 individuals, aged 30-69 years, BMI 25-37 kg/m

resultsBlood pressure and most fasting metabolic parameters improved at the end of the dietary intervention (time effect, p < 0.05 for all); however, no differences were observed between the low- and the high-GI MedDiet groups (time x group effect; p > 0.05 for all). Conversely, the low-GI diet, compared with high-GI diet, significantly reduced the 8-h triglyceride profile (p < 0.017, time*group effect) that was measured only in the Italian cohort. However, it induced a reduction of plasma triglycerides after lunch (tAUC) that was of only borderline statistically significance (p = 0.065).

conclusionsConsuming a low-GI in comparison with a high-GI MedDiet does not differentially affect the major cardiometabolic risk factors at fasting in individuals at increased cardiometabolic risk. Conversely, it could reduce postprandial plasma triglycerides. CLINICAL TRIAL REGISTRY NUMBER: NCT03410719, ( https://clinicaltrials.gov ).

Indexed as

Cardiometabolic Risk FactorsCardiovascular DiseasesDiet, MediterraneanGlycemic IndexAdultAgedBlood GlucoseBlood PressureDietary FiberFemaleHeart Disease Risk FactorsHumansItalyMaleMetabolic SyndromeMiddle AgedBlood GlucoseDietary FiberTriglycerides

Identifiers

PMID38267533

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.